Effect of amifostine, a radiation-protecting drug, on oxygen concentration in tissue measured by EPR oximetry and imaging.
Effect of amifostine, a radiation-protecting drug, on oxygen concentration in tissue measured by EPR oximetry and imaging.
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DOI：
10.3164/jcbn.15-130
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发表时间：
2017-05
影响因子：
2.4
通讯作者：
Anzai K
中科院分区：
文献类型：
--
作者：
Ueno M;Matsumoto S;Matsumoto A;Manda S;Nakanishi I;Matsumoto KI;Mitchell JB;Krishna MC;Anzai K
通过电子顺磁共振波谱和成像研究了防辐射药物氨磷汀对肌肉组织氧分压的影响。当给小鼠腹腔或静脉内施用氨磷汀时，植入小鼠腿部肌肉中的八正丁氧基取代的萘酞菁锂的电子顺磁共振谱的线宽减小。使用锂八正丁氧基取代的萘酞菁探针的电子顺磁共振血氧测定法和使用三芳基甲基自由基顺磁探针的电子顺磁共振氧图谱可用于量化活体小鼠组织中的氧压。电子顺磁共振血氧成像结果表明，给予氨磷汀可以降低肌肉和肿瘤组织中的氧压。这一发现表明，降低组织中的氧压可能部分有助于氨磷汀的辐射防护。
Effect of amifostine, a radiation-protecting drug, on muscle tissue partial pressure of oxygen was investigated by electron paramagnetic resonance spectroscopy and imaging. When amifostine was administered intraperitoneally or intravenously to mice, the linewidth of the electron paramagnetic resonance spectra of the lithium octa-n-butoxy-substituted naphthalocyanine implanted in the mouse leg muscle decreased. Electron paramagnetic resonance oximetry using a lithium octa-n-butoxy-substituted naphthalocyanine probe and electron paramagnetic resonance oxygen mapping using a triarylmethyl radical paramagnetic probe was useful to quantify pressure of oxygen in the tissues of living mice. The result of electron paramagnetic resonance oximetric imaging showed that administration of amifostine could decrease pressure of oxygen in the muscle and also tumor tissues. This finding suggests that lowering pressure of oxygen in tissues might contribute in part to the radioprotection of amifostine.