Patterns of Growth Associated With the Timing of Adiposity Rebound
Patterns of Growth Associated With the Timing of Adiposity Rebound
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DOI：
10.1038/oby.2008.547
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发表时间：
2009-02-01
期刊：
影响因子：
6.9
通讯作者：
Goulding, Ailsa
中科院分区：
文献类型：
--
作者：
Williams, Sheila M.;Goulding, Ailsa
本研究旨在评估肥胖反弹年龄（AR）对7至11岁之间的脂肪量、成熟度和肥胖的影响，研究对象为458名出生队列研究至26岁的儿童。3和26岁之间的增长模式和脂肪质量指数的变化7和11年之间的组与早期（= 7岁的女孩）进行了描述。在早期反弹组中，BMI、身高和体重的平均z评分在3岁和青春期之间增加，而在晚期反弹组中减少。这些差异一直持续到成年期的BMI和体重。在早期反弹组中，生长期间（7-11岁）脂肪质量指数不成比例的高增长，7岁时男孩的骨龄更早，女孩的初潮更早。26岁时超重（BMI 25-29.9 kg/m2）和肥胖（BMI = 30 kg/m2）的相对风险分别为2.70（95%置信区间（CI）：1.55，4.66）和5.91（95% CI：3.03，11.55），使用平均组作为参考。成人腰围超过国际分界点的相应相对危险度分别为2.12（95%CI：1.09，4.13）和3.32（95%CI：1.46，7.54）。因此，早期反弹与儿童中期脂肪沉积增加有关，与早期反弹相关的风险至少持续到成年早期。
This study was undertaken to evaluate the effects of age of adiposity rebound (AR) on measures of fat mass between ages 7 and 11 years, maturity, and adiposity in 458 children from a birth cohort studied to age 26 years. Patterns of growth between ages 3 and 26 years and changes in fat mass index between 7 and 11 years in groups with early (= 7 years for girls) are described. The mean z-scores for BMI, height, and weight increased between age 3 years and adolescence in the early-rebound group and decreased in the late-rebound group. The differences were maintained until adulthood for BMI and weight. Disproportionately high increases in fat mass index during growth (7-11 years), more advanced bone age in boys at age 7 years, and earlier menarche in girls were evident in the early-rebound group. The relative risks at 26 years of being overweight (BMI 25-29.9 kg/m(2)) and obese (BMI = 30 kg/m(2)) were 2.70 (95% confidence interval (CI): 1.55, 4.66) and 5.91 (95% CI: 3.03, 11.55) respectively, using the average group as the reference. The corresponding relative risks for adult waist girths exceeding international cut points were 2.12 (95% CI: 1.09, 4.13) and 3.32 (95% CI: 1.46, 7.54). Thus, early rebound is associated with increased depositions of fat in middle childhood, and risks associated with early rebound persist at least until early adulthood.