Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis
Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis
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DOI：
10.1002/nbm.907
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发表时间：
2004-10-01
影响因子：
2.9
通讯作者：
Ohtomo, K
中科院分区：
文献类型：
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作者：
Abe, O;Yamada, H;Ohtomo, K
本研究旨在探讨肌萎缩性侧索硬化症（ALS）患者体内水分子的扩散各向异性是否在锥体区和锥体外区被破坏。根据世界神经病学联合会的标准，我们研究了7例可能患有ALS的患者（4例女性，平均年龄+/-SD， 57.3+/-6.2岁）。对照组由11名年龄和性别匹配的志愿者组成（6名女性，57.1+/- 4.5），没有中枢神经系统疾病。采用统计参数映射（SPM99）进行基于体素的扩散张量分析。我们还根据弥散张量数据创建了归一化皮质脊髓束造影。ALS组右侧额叶回下白质和左侧额叶中央前白质分数各向异性（FA）显著降低。这些显著FA减少的簇与标准参考框架中皮质脊髓束的平均组图相吻合。这些结果提示，基于体素的弥散张量分析与弥散张量束成像相结合，可能有助于以无创的方式确定ALS患者受损神经元组织的位置。版权所有：John Wiley Sons， Ltd. 2004
The purpose of this study is to investigate whether the diffusional anisotropy of water molecules is disrupted in the pyramidal and extra-pyramidal regions in patients with amyotrophic lateral sclerosis (ALS). We studied seven patients with probable ALS (four women, mean age+/-SD, 57.3+/-6.2 years old) according to the criteria of the World Federation of Neurology. A control group consisted of 11 age- and sex-matched volunteers (six women, 57.1+/- 4.5) without disorders affecting the central nervous system. Voxel-based diffusion tensor analysis was made with statistical parametric mapping (SPM99). We also created the normalized corticospinal tractography from the diffusion tensor data. The significant fractional anisotropy (FA) decrease in the ALS group was found in the right frontal subgyral white matter and left frontal precentral white matter. These clusters with significant FA decrease corresponded well to the average group map of the corticospinal tract in a standard reference frame. These results suggested that the combination of voxel-based diffusion tensor analysis and diffusion tensor tractography might help determine the location of the affected neuronal tissues among ALS patients in a non-invasive manner. Copyright (C) 2004 John Wiley Sons, Ltd.