Life-course socioeconomic trajectories and diurnal cortisol regulation in adulthood
Life-course socioeconomic trajectories and diurnal cortisol regulation in adulthood
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DOI：
10.1016/j.psyneuen.2009.09.019
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发表时间：
2010-05-01
影响因子：
3.7
通讯作者：
Hammarstrom, Anne
中科院分区：
文献类型：
--
作者：
Gustafsson, Per E.;Janlert, Urban;Hammarstrom, Anne
虽然在生命过程中的社会经济不利的健康风险是相当确定的，机制研究较少。一个候选途径是皮质醇的长期失调。本研究评估了从青春期到成年的社会经济轨迹是否会影响成年中期皮质醇的调节，并进一步研究了青春期作为一个关键时期和社会经济劣势积累的重要性。参与者来自一项为期27年的前瞻性队列研究（n = 732，占原始队列的68%）。在16岁（基于父母职业）、21岁、30岁和43岁（基于自己的职业）时收集社会经济地位（SES）的信息，在43岁时，参与者在醒来时、15分钟后、午餐前和睡前收集一天的唾液皮质醇样本。我们发现，皮质醇觉醒反应（CAR）与SES轨迹不同;那些具有稳定的低或早期低/向上移动的SES的人往往比那些具有早期高/向下移动的，高度移动的或稳定的高轨迹的人表现出更高的CAR。进一步的分析显示，早期低SES与较高的CAR相关，女性低SES与较低的睡前皮质醇相关，独立于后期SES和潜在的混杂因素。我们没有发现支持的线性效应的积累的社会经济劣势。总之，我们的研究支持了生命早期低社会经济地位对成年期皮质醇调节的独立影响。(C)2009爱思唯尔有限公司保留所有权利。
Although the health risk of socioeconomic disadvantage over the life-course is fairly established, the mechanisms are less studied. One candidate pathway is long-term dysregulation of cortisol. This study assesses whether socioeconomic trajectories from adolescence to adulthood influences the regulation of cortisol in mid-adulthood, and further investigates the importance of adolescence as a critical period and of accumulation of socioeconomic disadvantage. Participants were drawn from a 27-year prospective cohort study (n = 732, 68% of the original cohort). Information on socioeconomic status (SES) was collected at the ages of 16 (based on parental occupation), 21, 30 and 43 (based on own occupation) years, and at 43 years participants collected one-day salivary cortisol samples at awakening, after 15 min, before lunch and at bedtime. We found that the cortisol awakening response (CAR) differed with respect to SES trajectory; those with stable low or early low/upwardly mobile SES tended to display higher CAR than those with early high/downwardly mobile, highly mobile or stable high trajectories. Further analyses revealed that early low SES was related to higher CAR, and in women low SES was related to lower bedtime cortisol, independently of later SES and potential confounders. We found no support for a linear effect of accumulation of socioeconomic disadvantage. In conclusion, our study gives support for an independent effect of low socioeconomic status early in life, on the regulation of cortisol in adulthood. (C) 2009 Elsevier Ltd. All rights reserved.