Apolipoprotein E-epsilon 2 and Alzheimer's disease: Genotype influences pathologic phenotype
Apolipoprotein E-epsilon 2 and Alzheimer's disease: Genotype influences pathologic phenotype
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DOI：
10.1212/wnl.48.2.515
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发表时间：
1997-02-01
期刊：
影响因子：
9.9
通讯作者：
Roses, AD
中科院分区：
文献类型：
--
作者：
Lippa, CF;Smith, TW;Roses, AD
为了确定载脂蛋白E β 2（APOE-ε 2）影响衰老和阿尔茨海默病（AD）的神经病理学，我们比较了β-淀粉样蛋白斑块在5名APOE-β 2/3 AD患者、5名APOE-β 3/3 AD患者、5名APOE-β 2/3对照患者中，和5例APOE-β 3/3对照患者。我们检查了（额叶和顶叶）新皮质、海马、内嗅皮质和小脑，发现APOE-β 2/3 AD患者皮质中的A β P密度低于APOE-β 3/3 AD患者（t = 3.121，p = 0.011）。APOE-12/3患者的淀粉样血管病变也少于APOE-3/3患者（U = 4.500，p = 0.027）。对照组APOE-β 2/3脑几乎没有AD相关的病理;即使是我们102岁的对照病例，与老年APOE-β 3/3病例相比，也几乎没有A β Ps。APOE-β 2/3基因型可能影响部分老年正常人群和AD人群的病理表型。
To determine whether apolipoprotein E epsilon 2 (APOE-epsilon 2) affects neuropathology in aging and Alzheimer's disease (AD), we compared beta-amyloid plaque (A beta P) and neurofibrillary tangle densities, neuropil thread formation, and amyloid angiopathy in five APOE-epsilon 2/3 AD patients, five APOE-epsilon 3/3 AD patients, five APOE-epsilon 2/3 control patients, and five APOE-epsilon 3/3 control patients. We examined the (frontal and parietal) neocortex, hippocampus, entorhinal cortex, and cerebellum and found A beta P densities to be lower (t = 3.121, p = 0.011) in the cortex of APOE-epsilon 2/3 AD patients than in APOE-epsilon 3/3 AD patients. Amyloid angiopathy was also less in APOE-epsilon 2/3 patients than in APOE-3/3 patients (U = 4.500, p = 0.027). Control APOE-epsilon 2/3 brains had little AD-related pathology; even our 102-year-old control case showed few A beta Ps compared with the elderly APOE-epsilon 3/3 cases. The APOE-epsilon 2/3 genotype may influence pathologic phenotype in some aged normal and AD populations.