Effects of pramipexole on impulsive choice in male wistar rats.
Effects of pramipexole on impulsive choice in male wistar rats.
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DOI：
10.1037/a0019244
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发表时间：
2010-06
影响因子：
2.3
通讯作者：
Fowler, Stephen C.
中科院分区：
文献类型：
--
作者：
Madden, Gregory J.;Johnson, Patrick S.;Brewer, Adam T.;Pinkston, Jonathan W.;Fowler, Stephen C.
临床报告，主要是帕金森病患者，注意到处方使用普拉克索（和其他直接作用的多巴胺受体激动剂药物）和冲动控制障碍，特别是病理性赌博之间的关联。两个实验检查了急性普拉克索对大鼠冲动选择的影响，其中冲动性被定义为选择较小的食物奖励而不是较大的食物奖励。在实验1中，普拉克索（0.1至0.3 mg/kg）在稳定基线期间很少做出冲动选择的条件下显著增加了冲动选择。在对照条件下，冲动选择在基线期间占主导地位，普拉克索没有显著改变相同大鼠的选择。实验2探索了更广泛的剂量范围（0.01至0.3毫克/公斤）使用的选择程序，其中延迟较大，较晚的药物输送增加在每个阶段内的试验块。在实验1中使用的剂量下，无论手术延迟如何，普拉克索都将选择转向无差别。在较低剂量的普拉克索（0.01和0.03 mg/kg）下，在0.03 mg/kg剂量下观察到更多冲动选择的趋势。实验结果的差异可能是由于实验2中所需的更复杂的区分;即，在每个会话内改变延迟之间的多重区分。
Clinical reports, primarily with Parkinson’s patients, note an association between the prescribed use of pramipexole (and other direct-acting dopamine agonist medications) and impulse control disorders, particularly pathological gambling. Two experiments examined the effects of acute pramipexole on rats’ impulsive choices where impulsivity was defined as selecting a smaller-sooner over a larger-later food reward. In Experiment 1, pramipexole (0.1 to 0.3 mg/kg) significantly increased impulsive choices in a condition in which few impulsive choices were made during a stable baseline. In a control condition, in which impulsive choices predominated during baseline, pramipexole did not significantly change the same rats’ choices. Experiment 2 explored a wider range of doses (0.01 to 0.3 mg/kg) using a choice procedure in which delays to the larger-later reinforcer delivery increased across trial blocks within each session. At the doses used in Experiment 1, pramipexole shifted choice toward indifference regardless of the operative delay. At lower doses of pramipexole (0.01 & 0.03 mg/kg), a trend toward more impulsive choice was observed at the 0.03 mg/kg dose. The difference in outcomes across experiments may be due to the more complex discriminations required in Experiment 2; i.e., multiple discriminations between changing delays within each session.
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影响因子：
2.3
作者：
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通讯作者：
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