Copper-Catalyzed Iminoiodane-Mediated Aminolactonization of Olefins: Application to the Synthesis of 5,5-Disubstituted Butyrolactones
Copper-Catalyzed Iminoiodane-Mediated Aminolactonization of Olefins: Application to the Synthesis of 5,5-Disubstituted Butyrolactones
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DOI：
10.1021/ol202436a
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发表时间：
2011-11-04
期刊：
影响因子：
5.2
通讯作者：
Dodd, Robert H.
中科院分区：
文献类型：
--
作者：
Karila, Delphine;Leman, Loic;Dodd, Robert H.
铜(I)催化多种4-芳基-4-戊烯酸酯与原位生成的壬基磺胺烷反应得到相应的5-芳基-5。nosylamidomethylbutyrolactones。该反应可能是通过一种可以分离的叠氮中间体进行的。
A copper(I)-catalyzed reaction of a variety of 4-aryl-pent-4-enoates with nosyliminolodane generated in situ provides the corresponding 5-aryl-5. nosylamidomethylbutyrolactones. The reaction presumably proceeds via an aziridine intermediate, which could be isolated in one case.