VDAC Channels
VDAC Channels
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DOI：
10.1080/15216540152845902
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发表时间：
2001
期刊：
影响因子：
4.6
通讯作者：
E. Blachly‐Dyson;M. Forte
中科院分区：
文献类型：
--
作者：
E. Blachly‐Dyson;M. Forte
认为代谢物穿过线粒体外膜的运输主要由成孔电压依赖性阴离子通道VDAC（也称为线粒体孔蛋白）介导。越来越多的体外研究强烈表明，由VDAC形成的孔可以以多种方式进行调节，这暗示它是调节线粒体功能的位点，但技术限制阻止了这些研究扩展到相关的细胞环境。这个简短的评论的目的是总结最近的数据，检查VDAC的作用和它的调节的背景下，而不是分离的蛋白质或细胞器，但在细胞中，集中在遗传策略的应用在一些实验系统。
Trafficking of metabolites across the outer mitochondrial membrane is believed to be mediated primarily by the pore‐forming voltage‐dependent anion channel, VDAC (also known as mitochondrial porin). An expanding body of in vitro studies have strongly suggest that the pore formed by VDAC can be regulated in a number of ways that implicate it as a site for the regulation of mitochondrial function, yet technical limitations have prevented the extension these studies to a relevant cellular context. The goal of this brief review is to summarize recent data that examine the role of VDAC and its regulation in the context not of the isolated protein or organelles but in cells, focusing on the application of genetic strategies in a number of experimental systems.