Human Th17 cells.
Human Th17 cells.
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DOI：
10.1186/ar2392
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发表时间：
2008
影响因子：
4.9
通讯作者：
Romagnani S
中科院分区：
文献类型：
--
作者：
Romagnani S
在小鼠中发现了一种新的CD 4+效应T辅助细胞（Th）谱系，可选择性地产生IL-17，这为免疫调节、宿主防御以及自身免疫和其他慢性炎症性疾病的发病机制提供了令人兴奋的新见解。这群CD 4 + Th细胞，被称为“Th 17”，确实在某些小鼠自身免疫模型的发病机制中起着明显的关键作用。有趣的是，鼠Th 17细胞与Foxp 3 + T调节细胞具有共同的起源，因为两个群体都是响应于转化生长因子-β而产生的，但它们仅在同时产生IL-6时才发育成Th 17细胞。对人类的初步研究已经证实了Th 17细胞的存在，但他们已经表明，这些细胞在人类中的起源与小鼠不同，IL-1β和IL-23是负责其发育的主要细胞因子。此外，在循环和各种组织中存在可产生IL-17和干扰素-γ的Th细胞，以及人Th 17克隆响应于IL-12除了产生IL-17之外还产生干扰素-γ的灵活性，表明至少在人类中，Th 17和Th 1细胞之间可能存在发育关系。解决这一问题对于建立Th 1和Th 17细胞在自身免疫性疾病中各自的致病作用具有重要意义。相反，Th 17细胞不太可能参与人过敏性IgE介导的疾病的发病机制，因为IL-4和IL-25（IL-4的强效诱导剂）都是Th 17细胞发育的有效抑制剂。
The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders. This population of CD4+ Th cells, which has been termed 'Th17', indeed plays an apparently critical role in the pathogenesis of some murine models of autoimmunity. Interestingly, murine Th17 cells share a common origin with Foxp3+ T regulatory cells, because both populations are produced in response to transforming growth factor-β, but they develop into Th17 cells only when IL-6 is simultaneously produced. Initial studies in humans have confirmed the existence of Th17 cells, but they have shown that the origin of these cells in humans differs from that in mice, with IL-1β and IL-23 being the major cytokines responsible for their development. Moreover, the presence in the circulation and in various tissues of Th cells that can produce both IL-17 and interferon-γ, as well as the flexibility of human Th17 clones to produce interferon-γ in addition to IL-17 in response to IL-12, suggests that there may be a developmental relationship between Th17 and Th1 cells, at least in humans. Resolving this issue has great implications in tems of establishing the respective pathogenic roles of Th1 and Th17 cells in autoimmune disorders. In contrast, it is unlikely that Th17 cells contribute to the pathogenesis of human allergic IgE-mediated disorders, because IL-4 and IL-25 (a powerful inducer of IL-4) are both potent inhibitors of Th17 cell development.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
4.4
作者：
Finnegan, A;Grusby, MJ;Zhang, J
通讯作者：
Zhang, J
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
4.4
作者：
Fitzgerald, Denise C.;Ciric, Bogoljub;Rostami, Abdolmohamad
通讯作者：
Rostami, Abdolmohamad