The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome: the ATTICA study
The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome: the ATTICA study
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DOI：
10.1097/00149831-200504000-00010
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发表时间：
2005-04-01
影响因子：
--
通讯作者：
Stefanadis, C
中科院分区：
文献类型：
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作者：
Pitsavos, C;Panagiotakos, DB;Stefanadis, C
目的代谢综合征是一种促进动脉粥样硬化、增加心血管疾病死亡率和发病率的疾病。方法从2001年5月到2002年12月，我们随机招募了1514名男性和1528名女性(>；18岁)，没有任何心血管疾病的临床证据，按年龄性别分层(人口普查2001)。这项研究的人群被分为符合NCEP ATP III代谢综合征标准的人(n=701或33%的男性和13%的女性)和其余的参与者(n=2341)。我们评估了自我报告的体力活动状态与炎症和凝血标志物[即C-反应蛋白(CRIP)、血清淀粉样蛋白(SAA)、白介素6(IL)-6、肿瘤坏死因子(TNF)-α、白细胞(WBC)和纤维蛋白原(FIB)]的关系。结果在非代谢综合征组中，56%的男性和58%的女性被归类为久坐不动，而在代谢综合征组中，58%的男性和72%的女性为久坐。在控制了各种潜在的混杂因素后，我们发现，与久坐不动相比，患有代谢综合征的体力活动个体的CRP水平降低36%，WBC水平降低15%，SAA水平降低19%，TNF-α水平降低15%，IL-6水平降低30%，FIB水平降低15%(均P<；0.05)。在非代谢综合征组中也观察到类似的结果。结论在代谢综合征患者中，采用体力活动的生活方式与所调查的生物标记物水平降低独立相关。后者可能提供了一种减少心血管事件的途径，即使是在高危人群中也是如此。(C)2005年欧洲心脏病学会。
Objective Metabolic syndrome is a condition that promotes atherosclerosis and increases the risk of cardiovascular mortality and morbidity. We evaluated whether leisure time physical activity is associated with the levels of inflammatory and coagulation markers, in people with metabolic syndrome.Methods From May 2001 to December 2002 we randomly enrolled 1514 men and 1528 women (> 18 years old), without any clinical evidence of cardiovascular disease, stratified by age-gender (census 2001). The population of the study was divided into those who fulfilled the NCEP ATP III criteria for the metabolic syndrome (n = 701 or 33% men and 13% women) and the rest of the participants (n = 2341). We assessed the relationship between self-reported physical activity status and inflammatory, and coagulation markers [i.e., C-reactive protein (CRIP), serum amyloid-A (SAA), interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, white blood cell (WBC) counts, and fibrinogen (FIB)], after taking into account the effect of several confounders.Results Of the non-metabolic syndrome group, 56% of men and 58% of women were classified as sedentary, while of the metabolic syndrome group 58% men and 72% women were sedentary. After controlling for various potential confounders we found that physically active individuals with the metabolic syndrome had 36% lower levels of CRP, 15% lower levels of WBC, 19% lower levels of SAA, 15% lower levels of TNF-alpha, 30% lower levels of IL-6 and 15% lower levels of FIB, compared to sedentary (all P < 0.05). Similar results were observed in the non-metabolic syndrome group.Conclusions The adoption of a physically active lifestyle is independently associated with lower levels of the investigated biomarkers in individuals with the metabolic syndrome. The latter may suggest a pathway for reducing cardiovascular events, even in high-risk people. (c) 2005 The European Society of Cardiology.