IR-GENE CONTROL OF IMMUNOGENICITY OF INSULIN AND A-CHAIN LOOP AS A CARRIER DETERMINANT
IR-GENE CONTROL OF IMMUNOGENICITY OF INSULIN AND A-CHAIN LOOP AS A CARRIER DETERMINANT
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DOI：
10.1038/254078a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
KECK, K
中科院分区：
文献类型：
--
作者：
KECK, K
一般认为，在辅助细胞识别抗原载体部分上的决定簇后，B细胞产生针对某些抗原的抗体。小鼠对几种抗原的免疫应答受Ir基因控制，Ir基因位于第IX小鼠连锁群的主要组织相容性（H-2）位点。Ir基因的功能细节仍然未知，但人们普遍认为它们控制着载体决定子的识别1，2。
IT is generally believed that the B cells produce antibody against certain antigens after the helper cells recognise a determinant on the carrier part of the antigen. The immune response in mice against several antigens is controlled by Ir-genes which map in the major histocompatibility (H-2) locus of the IXth mouse linkage group. Details of the function of the Ir-genes are still unknown, but it is generally accepted that they control the recognition of carrier determinants1,2.