Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging.
Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging.
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静息态功能磁共振成像显示患有和不患有腹痛的克罗恩病患者之间区域同质性的差异。
DOI：
10.1097/j.pain.0000000000000479
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发表时间：
2016-05
期刊：
影响因子：
7.4
通讯作者：
Wu HG
中科院分区：
文献类型：
--
作者：
Bao CH;Liu P;Liu HR;Wu LY;Jin XM;Wang SY;Shi Y;Zhang JY;Zeng XQ;Ma LL;Qin W;Zhao JM;Calhoun VD;Tian J;Wu HG
中枢神经系统异常的疼痛处理可能与克罗恩病（CD）患者的腹痛有关。本研究的目的是调查缓解期克罗恩病患者静息态大脑活动的变化及其与腹痛的关系。使用 3.0 T 功能磁共振成像 (fMRI) 扫描仪对 25 名有腹痛的 CD 患者、25 名无腹痛的 CD 患者和 32 名健康受试者进行了扫描。区域均匀性（ReHo）用于评估静息态大脑活动。在功能磁共振成像扫描前 1 周收集每日疼痛评分。我们发现腹痛患者的岛叶、中扣带皮层 (MCC) 和辅助运动区的 ReHo 值较低，而颞极的 ReHo 值较高。相反，无腹痛的患者海马/海马旁皮质 ReHo 值较低，背内侧前额叶皮质 ReHo 值较高（均 P<0.05，已校正）。腹痛患者岛叶和MCC的ReHo值与每日疼痛评分显着负相关（分别为r=-0.53，P=0.008和r=-0.61，P=0.002）。这些发现表明，有腹痛和无腹痛的缓解型 CD 患者的静息态大脑活动是不同的，并且岛叶和 MCC 的异常活动与腹痛的严重程度密切相关。
Abnormal pain processing in the central nervous system may be related to abdominal pain in patients with Crohn's disease (CD). The purpose of this study was to investigate changes in resting-state brain activity in CD patients in remission and its relationship with the presence of abdominal pain. Twenty-five CD patients with abdominal pain, 25 CD patients without abdominal pain, and 32 healthy subjects were scanned using a 3.0 T functional magnetic resonance imaging (fMRI) scanner. Regional homogeneity (ReHo) was used to assess resting-state brain activity. Daily pain scores were collected 1 week before fMRI scanning. We found that patients with abdominal pain exhibited lower ReHo values in the insula, middle cingulate cortex (MCC), and supplementary motor area, and higher ReHo values in the temporal pole. In contrast, patients without abdominal pain exhibited lower ReHo values in the hippocampal/parahippocampal cortex and higher ReHo values in the dorsomedial prefrontal cortex (all P<0.05, corrected). The ReHo values of the insula and MCC were significantly negatively correlated with daily pain scores for patients with abdominal pain (r=−0.53, P=0.008, and r=−0.61, P=0.002, respectively). These findings suggest that resting-state brain activities are different between remissive CD patients with and without abdominal pain, and that abnormal activities in insula and MCC are closely related to the severity of abdominal pain.