The Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID): Development of Case Report Forms for Global Use.
The Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID): Development of Case Report Forms for Global Use.
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DOI：
10.1007/s12028-020-01100-4
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发表时间：
2020-12
影响因子：
3.5
通讯作者：
Chou SHY
中科院分区：
文献类型：
--
作者：
McNett M;Fink EL;Schober M;Mainali S;Helbok R;Robertson CL;Mejia-Mantilla J;Kurtz P;Righy C;Roa JD;Villamizar-Rosales C;Altamirano V;Frontera JA;Maldonado N;Menon D;Suarez J;Chou SHY
自2020年1月首次报告以来，由严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）感染引起的2019年冠状病毒病（COVID-19）已迅速成为最致命的全球大流行病之一。早期报告显示可能与COVID-19相关的神经系统表现，症状从轻度到重度不等，患病率差异很大，症状的因果或巧合发生不确定。由于任何全身性疾病的神经系统受累往往与发病率和死亡率的不良影响相关，因此迫切需要获得关于COVID-19可能影响神经系统程度的准确和一致的全球数据。为了满足这一需求，神经危重症护理学会的研究人员启动了COVID-19神经功能障碍全球联盟研究（GCS-NeuroCOVID）。GCS-NeuroCOVID联盟迅速实施了一项一级实用研究，以确定COVID-19神经系统表现的表型和患病率。这种全球协作的一个关键组成部分是开发和应用公共数据元素（cde）和定义，以促进跨资源设置严格和系统的数据收集。这些要素的整合对于减少数据的异质性和未来高质量的荟萃分析至关重要。GCS-NeuroCOVID联盟专门设计了这些元素，以便在全球大流行期间，当医疗系统可能不堪重负，研究资源可能有限时，临床医生调查人员可以使用。内容包括儿科部分和翻译版本，以促进作为此次全球疫情中心之一的拉丁美洲的协作和数据采集。在本文中，我们分享了GCS-NeuroCOVID联盟一级成人和儿童CDEs的具体数据要素、定义和基本原理，以及适用于拉丁美洲使用的翻译版本。全球正在努力进一步协调CDEs与其他研究COVID-19感染的神经学和一般方面的大型联盟。最终，GCS-NeuroCOVID联盟网络为系统地获取当前和未来意外灾害和疾病暴发的数据提供了关键基础设施。
Since its original report in January 2020, the coronavirus disease 2019 (COVID-19) due to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection has rapidly become one of the deadliest global pandemics. Early reports indicate possible neurological manifestations associated with COVID-19, with symptoms ranging from mild to severe, highly variable prevalence rates, and uncertainty regarding causal or coincidental occurrence of symptoms. As neurological involvement of any systemic disease is frequently associated with adverse effects on morbidity and mortality, obtaining accurate and consistent global data on the extent to which COVID-19 may impact the nervous system is urgently needed. To address this need, investigators from the Neurocritical Care Society launched the Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID). The GCS-NeuroCOVID consortium rapidly implemented a Tier 1, pragmatic study to establish phenotypes and prevalence of neurological manifestations of COVID-19. A key component of this global collaboration is development and application of common data elements (CDEs) and definitions to facilitate rigorous and systematic data collection across resource settings. Integration of these elements is critical to reduce heterogeneity of data and allow for future high-quality meta-analyses. The GCS-NeuroCOVID consortium specifically designed these elements to be feasible for clinician investigators during a global pandemic when healthcare systems are likely overwhelmed and resources for research may be limited. Elements include pediatric components and translated versions to facilitate collaboration and data capture in Latin America, one of the epicenters of this global outbreak. In this manuscript, we share the specific data elements, definitions, and rationale for the adult and pediatric CDEs for Tier 1 of the GCS-NeuroCOVID consortium, as well as the translated versions adapted for use in Latin America. Global efforts are underway to further harmonize CDEs with other large consortia studying neurological and general aspects of COVID-19 infections. Ultimately, the GCS-NeuroCOVID consortium network provides a critical infrastructure to systematically capture data in current and future unanticipated disasters and disease outbreaks.
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影响因子：
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