Hashimoto’s encephalopathy mimicking spinocerebellar ataxia
Hashimoto’s encephalopathy mimicking spinocerebellar ataxia
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桥本脑病模仿脊髓小脑性共济失调
DOI：
10.1007/s00415-011-5976-2
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发表时间：
2011
影响因子：
6
通讯作者：
J. Jia
中科院分区：
文献类型：
--
作者：
Yi;Changbiao Chu;M. Lin;Gangzhi Wei;Xinqing Zhang;Y. Da;Hui Huang;J. Jia
一名39岁的男性因步态困难、虚弱和构音障碍恶化而入院治疗。他的症状在17个月前出现，步态不稳。随后，他逐渐出现书写困难、虚弱和构音障碍。他的症状在当地一家医院被认为是脊髓小脑性共济失调，并接受了辅酶Q10和维生素B1和B12的治疗。没有观察到任何改善。他的残疾在入院前两周加速。没有小脑症状的家族史。体检显示可触及甲状腺。神经系统检查显示精神状态正常，右侧中央面部无力，舌束，下巴剧烈抽动，呕吐反射亢进，扫描构音障碍。左、上、右肢体力量4/5，双侧掌侧反射，右侧巴宾斯基征。右手可见局限性肌张力障碍。他只能走几步路，步态宽广，共济失调。已标记的
A 39-year-old man was admitted for complaints of worsening gait difficulty, weakness and dysarthria. His symptoms had developed 17 months earlier with unsteadiness of gait. Subsequently, he gradually developed difficulties in handwriting, weakness and dysarthria. His symptoms were considered as spinocerebellar ataxia in a local hospital and treated with CoQ10, and vitamins B1 and B12. No improvement was observed. His disability accelerated 2 weeks prior to admission. There is no family history of cerebellar symptoms.Physical examination revealed palpable thyroid gland. Neurological examination showed normal mental status, right central facial weakness, lingual fasciculations, brisk jaw jerk, hyperactive gag reflex and scanning dysarthria. Strength of left upper and right limbs was 4/5 with bilateral palmomental reflexes and right Babinski signs. Focal dystonia was observed in the right hand. He was only able to walk several steps, with broad-based, ataxic gait. Marked