Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness
Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness
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DOI：
10.1016/s0014-2999(02)02237-9
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发表时间：
2002-09-27
影响因子：
5
通讯作者：
Chung, KF
中科院分区：
文献类型：
--
作者：
Eynott, PR;Groneberg, DA;Chung, KF
The role of nitric oxide (NO) in allergic inflammation and bronchial hyperresponsiveness is unclear. We studied a selective prodrug nitric oxide synthase (NOS)-2 inhibitor, L-N-6-(1-iminoethyl)lysine 5-tetrazole amide (SC-51). In ovalbumin-sensitized and challenged rats, exhaled NO levels increased by 3 It following challenge (3.73 +/- 0.74 ppb; P< 0.05), peaking at 9 h (11.0 +/- 2.75; P< 0.01) compared to saline controls (1.87 +/- 0.26; P < 0.05 and 2.81 +/- 0.18; P < 0.0 1). Immunoreactive lung NOS2 expression was increased in ovalbumin-challenged rats compared with ovalbumin-sensitized, saline-challenged rats at 8 h post-challenge. SC-51 (10 mg/kg; p.o.) inhibited allergen-induced increase in exhaled NO levels to 1.3 +/- 0.17 ppb. SC-51 inhibited bronchial hyperresponsiveness in ovalbumin-sensitized and challenged rats (P
