RENAL AFFERENT DENERVATION PREVENTS HYPERTENSION IN RATS WITH CHRONIC-RENAL-FAILURE
RENAL AFFERENT DENERVATION PREVENTS HYPERTENSION IN RATS WITH CHRONIC-RENAL-FAILURE
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DOI：
10.1161/01.hyp.25.4.878
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发表时间：
1995-04-01
期刊：
影响因子：
8.3
通讯作者：
KOGOSOV, E
中科院分区：
文献类型：
--
作者：
CAMPESE, VM;KOGOSOV, E
交感神经系统的活动增加已被描述在慢性肾功能衰竭，但其作用的发生和维持高血压与这种情况尚未建立。肾脏有一个强烈的化学感受器和压力感受器网络，将脉冲发送到大脑。瘢痕肾或尿毒症环境对这些受体的激活在多大程度上可能导致这种高血压模型尚不清楚。在本研究中，我们评估了双侧背根切断术对5/6肾切除术或假手术的Sprague-Dawley大鼠的下丘脑前、外侧和后核、蓝斑和孤束核中高血压和神经肾上腺素能活动的发展的影响。通过计算用α-甲基-DL-β-酪氨酸甲酯盐酸盐抑制去甲肾上腺素合成后的去甲肾上腺素周转率来测定神经肾上腺素能活性。内源性去甲肾上腺素浓度显着更大的后，外侧下丘脑核和蓝斑，但不是在孤束核，和下丘脑前核的尿毒症大鼠与对照组相比。在慢性肾功能衰竭和假神经根切断术的大鼠中，后部去甲肾上腺素的周转率（15.3 +/- 1.61 nmol . g（-1）。h（-1））和下丘脑外侧核（11.7 ± 2.12 nmol . g（-1）。h（-1））和蓝斑（26.6 ± 2.42 nmol . g（-1）。h（-1））显著加快（P
Increased activity of the sympathetic nervous system has been described in chronic renal failure, but its role in the genesis and maintenance of hypertension associated with this condition has not been established. The kidney has an intense network of chemoreceptors and baroreceptors that send impulses to the brain. To what extent activation of these receptors by the scarred kidney or the uremic milieu may contribute to this model of hypertension is unknown. In the present study, we evaluated the effect of bilateral dorsal rhizotomy on the development of hypertension and neuroadrenergic activity in the anterior, lateral, and posterior hypothalamic nuclei, in the locus ceruleus, and in the nucleus tractus solitarius of Sprague-Dawley rats that underwent 5/6 nephrectomy or were sham operated. Neuroadrenergic activity was determined by calculating norepinephrine turnover rate after inhibition of norepinephrine synthesis with alpha-methyl-DL-p-tyrosine methyl ester hydrochloride. The endogenous norepinephrine concentration was significantly greater in the posterior and lateral hypothalamic nuclei and the locus ceruleus, but not in the nucleus tractus solitarius, and the anterior hypothalamic nuclei of uremic rats compared with control rats. In rats with chronic renal failure and sham rhizotomy, the turnover rate of norepinephrine in the posterior (15.3 +/- 1.61 nmol . g(-1) . h(-1)) and lateral hypothalamic nuclei (11.7 +/- 2.12 nmol . g(-1) . h(-1)) and in the locus ceruleus (26.6 +/- 2.42 nmol . g(-1) . h(-1)) was significantly faster (P