FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH - RESULTS FROM 3-YEAR FOLLOW-UP
FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH - RESULTS FROM 3-YEAR FOLLOW-UP
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DOI：
10.1016/0140-6736(90)90080-o
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发表时间：
1990-02-03
期刊：
影响因子：
168.9
通讯作者：
HOLMGREN, J
中科院分区：
文献类型：
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作者：
CLEMENS, JD;SACK, DA;HOLMGREN, J
在孟加拉国农村2-15岁儿童和15岁以上妇女的随机双盲现场试验中，评估了B亚单位杀死全细胞（BS-WC）和杀死全细胞（WC）口服霍乱疫苗的保护功效（PE）。在62,285名接受三剂BS-WC、WC或大肠杆菌K12菌株安慰剂的受试者中，BS-WC组3年随访时的累积PE为50%，WC组为52%。严重和非严重霍乱的PE相似，但2-5岁时接种疫苗的儿童（BS-WC为26%，WC为23%）的PE明显低于老年人（BS-WC为63%，WC为68%）。在2-5岁接种疫苗的人中，随访4-6个月时的保护作用与老年人相似，但此后迅速减弱，并且在随访的第三年不明显。相比之下，年龄较大接种疫苗的人即使在随访的第三年也受到保护（BS-WC的PE为40%；WC的PE为62%）。典型霍乱的PE （BS-WC为58%，WC为60%）明显高于El Tor霍乱（39%和40%）。
The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62,285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was siilar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).