Transcriptome analysis and co-expression network reveal the mechanism linking mitochondrial function to immune regulation in red crucian carp (Carassius auratus red var) after Aeromonas hydrophila challenge.
Transcriptome analysis and co-expression network reveal the mechanism linking mitochondrial function to immune regulation in red crucian carp (Carassius auratus red var) after Aeromonas hydrophila challenge.
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DOI：
10.1111/jfd.13677
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发表时间：
2022-06
影响因子：
2.5
通讯作者：
Ning Xiong;Xuebing Kuang;Zijie Fang;Jie Ou;Shi-yun Li;Jia-hui Zhao;Jin-Fang Huang;Ke-Xin Li;Roup Wang;L. Fan;Sheng-Wei Luo;Shao-Jun Liu
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作者：
Ning Xiong;Xuebing Kuang;Zijie Fang;Jie Ou;Shi-yun Li;Jia-hui Zhao;Jin-Fang Huang;Ke-Xin Li;Roup Wang;L. Fan;Sheng-Wei Luo;Shao-Jun Liu
嗜水气单胞菌是淡水鱼的常见病原菌。在本研究中，A.研究表明，红鲫（Red Crucian Carp，RCC）感染后可引起组织损伤、生理变化以及免疫和代谢相关基因的表达谱改变。转录组分析表明，急性A。Escherichia感染对线粒体氧化磷酸化产生了深远的影响，将代谢调节与免疫反应联系起来。此外，我们进一步确定了细胞衰老、凋亡、坏死和丝裂原活化蛋白激酶信号通路是A.尿道感染。这些发现可能对理解细菌感染的免疫代谢反应的调节具有重要意义。
Aeromonas hydrophila is a common pathogen of freshwater fish. In this study, A. hydrophila infection was shown to cause tissue damage, trigger physiological changes as well as alter the expression profiles of immune- and metabolic-related genes in immune tissues of red crucian carp (RCC). Transcriptome analysis revealed that acute A. hydrophila infection exerted a profound effect on mitochondrial oxidative phosphorylation linking metabolic regulation to immune response. In addition, we further identified cellular senescence, apoptosis, necrosis and mitogen-activated protein kinase signal pathways as crucial signal pathways in the kidney of RCC subjected to A. hydrophila infection. These findings may have important implications for understanding modulation of immunometabolic response to bacterial infection.