Increased circulating fibrocytes are associated with higher reticulocyte percent in children with sickle cell anemia.
Increased circulating fibrocytes are associated with higher reticulocyte percent in children with sickle cell anemia.
复制标题
镰状细胞性贫血儿童的循环纤维细胞增加与网织红细胞百分比升高相关。
DOI：
10.1002/ppul.23248
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发表时间：
2016
影响因子：
3.1
通讯作者：
Field,JoshuaJ
中科院分区：
文献类型：
--
作者：
Karafin,MatthewS;Dogra,Shibani;Rodeghier,Mark;Burdick,Marie;Mehrad,Borna;Rose,CEdward;Strieter,RobertM;DeBaun,MichaelR;Strunk,RobertC;Field,JoshuaJ
研究背景间质性肺疾病在镰状细胞性贫血（SCA）患者中很常见。纤维细胞是循环细胞，参与哮喘肺纤维化和气道重塑的发病机制。在这项研究中，我们测试了纤维细胞水平的假设：（1）与健康对照组相比，SCA儿童的纤维细胞水平增加;（2）与肺部疾病相关。ProcedureCross-sectional cohort study of children with SCA who participated in the Sleep Asthma Cohort Study.ResultsFibrocyte levels were obtained from 45 children with SCA and 24 controls. SCA病例的平均年龄为14岁，53%为女性。SCA患儿循环纤维细胞水平高于对照组（P< 0.01）。纤维细胞表达趋化因子受体的层次，CXCR 4在大多数细胞上表达，CCR 2和CCR 7在较小的子集上表达。几乎一半的纤维细胞表现出α-平滑肌肌动蛋白活化。SCA患儿纤维细胞水平升高与网织红细胞计数升高（P= 0.03）和年龄增大（P= 0.048）相关。然而，纤维细胞水平增加的儿童并不更有可能有哮喘或较低的百分比预测用力呼气容积在1秒/用力肺活量（FEV 1/FVC）或FEV 1比那些较低的fibrocytelevel.ConclusionsHigher水平的纤维细胞在儿童SCA相比，控制可能是由于溶血。纵向研究可能能够更好地评估纤维细胞水平和肺功能障碍之间的关系。2016;51：295-299.© 2015 Wiley Periodicals，Inc.
BackgroundInterstitial lung disease is common in patients with sickle cell anemia (SCA). Fibrocytes are circulating cells implicated in the pathogenesis of pulmonary fibrosis and airway remodeling in asthma. In this study, we tested the hypotheses that fibrocyte levels are: (1) increased in children with SCA compared to healthy controls, and (2) associated with pulmonary disease.ProcedureCross‐sectional cohort study of children with SCA who participated in the Sleep Asthma Cohort Study.ResultsFibrocyte levels were obtained from 45 children with SCA and 24 controls. Mean age of SCA cases was 14 years and 53% were female. In children with SCA, levels of circulating fibrocytes were greater than controls (P< 0.01). The fibrocytes expressed a hierarchy of chemokine receptors, with CXCR4 expressed on the majority of cells and CCR2 and CCR7 expressed on a smaller subset. Almost half of fibrocytes demonstrated α‐smooth muscle actin activation. Increased fibrocyte levels were associated with a higher reticulocyte count (P= 0.03) and older age (P= 0.048) in children with SCA. However, children with increased levels of fibrocytes were not more likely to have asthma or lower percent predicted forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC) or FEV1than those with lower fibrocyte levels.ConclusionsHigher levels of fibrocytes in children with SCA compared to controls may be due to hemolysis. Longitudinal studies may be able to better assess the relationship between fibrocyte level and pulmonary dysfunction.Pediatr Pulmonol. 2016;51:295–299. © 2015 Wiley Periodicals, Inc.