The synthesis of chiral isotetronic acids with amphiphilic imidazole/pyrrolidine catalysts assembled in oil-in-water emulsion droplets.
The synthesis of chiral isotetronic acids with amphiphilic imidazole/pyrrolidine catalysts assembled in oil-in-water emulsion droplets.
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DOI：
10.1002/anie.201206438
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发表时间：
2012-12
影响因子：
--
通讯作者：
Boyu Zhang;Zongxuan Jiang;Xin Zhou;Sheng-mei Lu;Jun Li;Yan Liu;Can Li
中科院分区：
文献类型：
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作者：
Boyu Zhang;Zongxuan Jiang;Xin Zhou;Sheng-mei Lu;Jun Li;Yan Liu;Can Li
放下枪以水为溶剂，在该催化剂的催化下，α-酮酸和醛的级联反应具有很高的对映选择性。荧光成像显示催化剂主要分布在乳液液滴表面。用该方法可以得到光学活性的异特窗酸，其高反应活性和对映选择性是由乳液滴决定的。
Drop it! A highly enantioselective catalytic cascade reaction of α-ketoacids and aldehydes is achieved using the title catalyst and water as the solvent. Fluorescence imaging shows that the catalyst is mainly distributed on the surface of emulsion droplets. Optically active isotetronic acids can be obtained with this method and the emulsion droplets are responsible for the high reactivity and enantioselectivity.