Efficacy of Percutaneous Cementoplasty for Bone Metastasis from Hepatocellular Carcinoma
Efficacy of Percutaneous Cementoplasty for Bone Metastasis from Hepatocellular Carcinoma
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DOI：
10.1159/000113040
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发表时间：
2008-01
期刊：
影响因子：
3.5
通讯作者：
Hideaki Kodama;H. Aikata;K. Uka;S. Takaki;N. Mori;K. Waki;S. Jeong;Y. Kawakami;Hiroo Shirakawa-Hiroo-Shiraka
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文献类型：
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作者：
Hideaki Kodama;H. Aikata;K. Uka;S. Takaki;N. Mori;K. Waki;S. Jeong;Y. Kawakami;Hiroo Shirakawa-Hiroo-Shiraka
目的：评价经皮骨水泥成形术治疗原发性肝癌骨转移疼痛的疗效。方法：对13例22个骨转移瘤患者行骨水泥成形术。所有患者均有顽固性疼痛，并被诊断为肝癌骨转移瘤。在CT引导下将骨针插入骨转移部位的中心。采用VAS评分、Tokuhashi评分和Frankel评分评价骨水泥成形术的疗效。我们还评估了对治疗的反应、不良事件和预后。结果：骨水泥成形术后仅VAS评分改善，而Tokuhashi和Frankel评分无改善。骨转移疼痛的骨水泥成形术可缓解严重疼痛，但不能改善预后、神经功能或生存率。13例患者中有11例（85%）显示CR或PR，平均无痛期为5个月，其中1例无痛期为10个月。未发生严重并发症。结论：经皮骨水泥成形术可以缓解疼痛，改善生活质量，但没有生存的好处，肝癌患者疼痛的骨转移。
Objective: To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). Methods: Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was inserted in the center of the site of bone metastasis under CT guidance. VAS score, Tokuhashi score and Frankel score were used for assessment of the efficacy of cementoplasty. We also assessed the response to treatment, adverse events and prognosis. Results: Only the VAS score, but not Tokuhashi and Frankel scores, improved after cementoplasty. Cementoplasty for painful bone metastasis provided relief of severe pain but did not improve prognosis, neurological function or survival. Eleven of 13 (85%) patients showed CR or PR and the mean pain-free period was 5 months, including a 10-month pain-free period in one case. No major complications were encountered. Conclusions: Percutaneous cementoplasty can provide pain relief and improvement of quality of life, though without survival benefits, for HCC patients with painful bone metastasis.