Auditory Event-Related Response in Visual Cortex Modulates Subsequent Visual Responses in Humans
Auditory Event-Related Response in Visual Cortex Modulates Subsequent Visual Responses in Humans
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DOI：
10.1523/jneurosci.1076-11.2011
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发表时间：
2011-05-25
影响因子：
5.3
通讯作者：
Herrmann, Christoph S.
中科院分区：
文献类型：
--
作者：
Naue, Nicole;Rach, Stefan;Herrmann, Christoph S.
越来越多的证据表明，从动物和人类研究的电生理数据表明，多感官的相互作用不仅是一个高阶的过程，但也发生在初级感觉皮层。这种早期的多感觉相互作用被认为是通过相位重置来介导的。对一种感觉模态的刺激的呈现重置了另一种模态中正在进行的振荡的相位，使得后一种模态中的处理被调制。在人类中，这种机制的证据仍然很少。在目前的研究中，听觉刺激对视觉加工的影响进行了研究，通过测量脑电图（EEG）和行为反应的人的视觉，听觉和视听刺激与不同的刺激起始时间（SOA）。我们在我们的数据中观察到三种不同的振荡EEG反应。最初的伽马波段响应约为50 Hz，随后是β波段响应约为25 Hz，θ波段响应约为6 Hz。后者是增强响应跨模态刺激相比，无论是单峰刺激。有趣的是，对单峰听觉刺激的β反应在电极中占主导地位。听觉和视觉刺激之间的SOA--尽管不是有意识地感知到的--对多感觉诱发的β-波段反应有调节作用;即，振幅以正弦方式依赖于SOA，表明相位重置。这些发现进一步支持了这样的观点，即脑振荡的参数，如振幅和相位是随后的大脑反应的重要预测因子，可能是多感觉整合的机制之一。
Growing evidence from electrophysiological data in animal and human studies suggests that multisensory interaction is not exclusively a higher-order process, but also takes place in primary sensory cortices. Such early multisensory interaction is thought to be mediated by means of phase resetting. The presentation of a stimulus to one sensory modality resets the phase of ongoing oscillations in another modality such that processing in the latter modality is modulated. In humans, evidence for such a mechanism is still sparse. In the current study, the influence of an auditory stimulus on visual processing was investigated by measuring the electroencephalogram (EEG) and behavioral responses of humans to visual, auditory, and audiovisual stimulation with varying stimulus-onset asynchrony (SOA). We observed three distinct oscillatory EEG responses in our data. An initial gamma-band response around 50 Hz was followed by a beta-band response around 25 Hz, and a theta response around 6 Hz. The latter was enhanced in response to cross-modal stimuli as compared to either unimodal stimuli. Interestingly, the beta response to unimodal auditory stimuli was dominant in electrodes over visual areas. The SOA between auditory and visual stimuli-albeit not consciously perceived-had a modulatory impact on the multisensory evoked beta-band responses; i.e., the amplitude depended on SOA in a sinusoidal fashion, suggesting a phase reset. These findings further support the notion that parameters of brain oscillations such as amplitude and phase are essential predictors of subsequent brain responses and might be one of the mechanisms underlying multisensory integration.