Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells
Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells
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DOI：
10.1016/j.jhazmat.2020.123417
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发表时间：
2021-01-05
影响因子：
13.6
通讯作者：
Antherieu, Sebastien
中科院分区：
文献类型：
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作者：
Dusautoir, Romain;Zarcone, Gianni;Antherieu, Sebastien
电子香烟（e-cigs）和最近的加热烟草产品（HTP）为吸烟者提供了替代品，因为它们通常被认为比传统香烟危害更小。然而，关键是要比较这些不同的紧急设备的健康风险，以确定哪种产品应该优先替代香烟。本研究旨在比较HTP，电子烟和传统香烟的排放物组成，关于选定的有害或潜在有害化合物，以及它们对人支气管上皮BEAS-2B细胞的毒性影响。HTP卷烟的多环芳烃和羰基化合物排放量低于传统卷烟。然而，HTP气溶胶中这些化合物的含量仍然高于电子烟蒸汽。与香烟烟雾相比，HTP气溶胶显示出降低的细胞毒性，但高于电子烟蒸气。HTP和电子烟有可能增加氧化应激和炎症反应，其方式类似于香烟烟雾，但在更密集的暴露之后。此外，增加电子烟功率会影响某些有毒化合物和相关氧化应激的水平。这项研究为风险评估提供了重要数据，证明HTP可能比烟草卷烟危害小，但比电子烟危害大得多。
The electronic cigarettes (e-cigs) and more recently the heated tobacco products (HTP) provide alternatives for smokers as they are generally perceived to be less harmful than conventional cigarettes. However, it is crucial to compare the health risks of these different emergent devices, in order to determine which product should be preferred to substitute cigarette. The present study aimed to compare the composition of emissions from HTP, e-cigs and conventional cigarettes, regarding selected harmful or potentially harmful compounds, and their toxic impacts on the human bronchial epithelial BEAS-2B cells. The HTP emitted less polycyclic aromatic hydrocarbons and carbonyls than the conventional cigarette. However, amounts of these compounds in HTP aerosols were still higher than in e-cig vapours. Concordantly, HTP aerosol showed reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours. HTP and e-cig had the potential to increase oxidative stress and inflammatory response, in a manner similar to that of cigarette smoke, but after more intensive exposures. In addition, increasing e-cig power impacted levels of certain toxic compounds and related oxidative stress. This study provides important data necessary for risk assessment by demonstrating that HTP might be less harmful than tobacco cigarette but considerably more harmful than e-cig.