Rolandic epilepsy has little effect on adult life 30 years later
Rolandic epilepsy has little effect on adult life 30 years later
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DOI：
10.1212/wnl.0000000000000267
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发表时间：
2014-04-01
期刊：
影响因子：
9.9
通讯作者：
Camfield, Peter R.
中科院分区：
文献类型：
--
作者：
Camfield, Carol S.;Camfield, Peter R.
目的：探讨儿童期罗兰癫痫的成人社会结局。方法：从新斯科舍省儿童癫痫前瞻性人群队列中确定药物治疗的罗兰性癫痫患者。癫痫发作时间为1977-1985年，随访时间为2010-2013年，对21岁以上患者进行图表回顾和结构化电话访谈。结果：42名儿童发生罗兰性癫痫（占队列中692例癫痫病例的6%）。其中32人（76%）的年龄超过21岁。癫痫发作平均7.7 2.3年，随访29.5 +/- 2.8年，最终年龄37 +/- 3.4年。所有患者癫痫缓解，停用抗癫痫药物21.4 +/- 6.6年。有2人因癫痫而受轻伤，只有1人死亡（死于雪地摩托事故）。总体而言，41%的人有7项不良社会后果中的1项，6项有1项，4项有2项，3项有3项。这些因素包括：未完成高中学业（n = 7），在稳定关系之外怀孕（n = 1），以及贫穷（n = 2）。那些没有完成高中学业的人更有可能有低学业成绩和/或低收入的父母（p < 0.02）。相比之下，该队列中智力正常的其他癫痫患者的不良社会结果率从62%到76%不等。结论：罗兰癫痫患儿的成人社会结局明显好于智力正常的其他主要癫痫患儿。
Objective:To establish the adult social outcome for childhood-onset rolandic epilepsy.Methods:Patients with medication-treated rolandic epilepsy were identified from the Nova Scotia prospective population-based cohort of childhood-onset epilepsy. Epilepsy onset was in 1977-1985 and follow-up was in 2010-2013 with chart review plus structured telephone interview for those older than 21 years.Results:Forty-two children developed rolandic epilepsy (6% of 692 incident epilepsy cases in the cohort). Thirty-two (76%) were contacted when they were older than 21 years. Epilepsy onset averaged 7.7 2.3 years, follow-up 29.5 +/- 2.8 years, and final age 37 +/- 3.4 years. All had epilepsy remission and were off antiepileptic drug treatment for 21.4 +/- 6.6 years. There were 2 minor injuries from seizures and only 1 death (from a snowmobile accident). Overall, 41% had 1 of 7 adverse social outcomes, 6 had 1, 4 had 2, and 3 had 3. These were failure to complete high school (n = 7), pregnancy outside of a stable relationship (3 months (n = 1), and poverty (n = 2). Those who did not complete high school were more likely to have parents with low academic achievement and/or low income (p < 0.02). By comparison, rates of 1 adverse social outcomes for other epilepsies with normal intelligence from this cohort varied from 62% to 76%.Conclusions:The adult social outcome for children with rolandic epilepsy is remarkably better than for those with other major epilepsies and normal intelligence.