Octyl substituted butenolides from marine-derived Streptomyces koyangensis
Octyl substituted butenolides from marine-derived Streptomyces koyangensis
复制标题
来自海洋来源的高阳链霉菌的辛基取代的丁烯内酯
DOI：
10.1080/14786419.2019.1686368
复制
发表时间：
2019-11-05
影响因子：
2.2
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Huang, Hongbo;Song, Yongxiang;Ju, Jianhua
从海洋来源的大洋链霉菌SCSIO 5802中分离得到一个新的丁烯内酯衍生物(1)，它具有伽马位置上的辛基取代特征，以及四个已知的类似物(2-5)。1的结构经HR-MS和核磁共振波谱数据分析确证。通过与已知化合物的圆二色谱比较，确定了1的内酯环立体中心的绝对构型。化合物1对单纯疱疹病毒有温和的抗病毒活性，EC50值为25.4 mU/M。
A new butenolide derivative (1) featuring octyl substitution at gamma-position, together with four known analogues (2-5) were isolated from marine-derived Streptomyces koyangensis SCSIO 5802. The structure of 1 was elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configuration of the stereo centre in lactone ring of 1 was determined by comparison of CD spectrum with those of known compounds. Compound 1 exhibited mild antiviral activity against herpes simplex virus with EC50 value of 25.4 mu M.