Elevated nocturnal profiles of serum leptin in patients with depression
Elevated nocturnal profiles of serum leptin in patients with depression
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DOI：
10.1016/s0022-3956(98)00032-6
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发表时间：
1998-11-01
影响因子：
4.8
通讯作者：
Steiger, A
中科院分区：
文献类型：
--
作者：
Antonijevic, IA;Murck, H;Steiger, A
瘦素是肥胖(Ob)基因的蛋白质产物，已被认为在调节食物摄入量方面发挥作用。由于抑郁发作的特征通常是食欲不振、进食量减少和体重减轻，因此抑郁症患者的瘦素分泌也可能发生变化。因此，我们检查了夜间(晚上10点)。至上午7时)15例抑郁症患者和年龄、性别匹配的对照组(年龄23-71岁)的瘦素、皮质醇、ACTH和生长激素(GH)的分泌。此外，我们还研究了脉冲式给予生长激素释放激素(GHRH)对夜间激素分泌的影响。GHRH被认为是促肾上腺皮质激素释放激素(CRH)的内源性拮抗剂，而CRH被认为在抑郁症的病理生理学中起关键作用。抑郁症患者夜间皮质醇分泌有升高趋势(F=3.8，p<；0.05)。尽管有体重减轻的报道，但患者夜间血清瘦素水平显著升高(F=8，P
Leptin, the protein product of the obese (ob) gene, has been suggested to play a role in the regulation of food intake. As depressive episodes are frequently characterized by loss of appetite, reduced food intake and weight loss, altered leptin secretion might also be expected in patients with depression. Therefore, we examined nocturnal (10.00 p.m. to 7.00 a.m.) secretion of leptin, cortisol, ACTH and growth hormone (GH) in a group of 15 patients with depression and age- and sex-matched controls (age range 23-71 years). In addition, the effects of pulsatile administration of growth hormone-releasing hormone (GHRH), thought to be an endogenous antagonist of corticotropin-releasing hormone (CRH), which in turn is believed to play a critical role for the pathophysiology of depression, on nocturnal hormone secretion were assessed. Patients with depression showed a trend towards elevated nocturnal cortisol secretion (F= 3.8, p < 0.05). Nocturnal serum leptin was significantly higher in patients, despite a reported weight loss (F= 8, p