Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows
Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows
复制标题
通过优化重合时间窗提高砹211康普顿成像的性能
DOI：
10.1088/1748-0221/16/12/c12031
复制
发表时间：
2021
影响因子：
1.3
通讯作者：
Watabe H.
中科院分区：
文献类型：
--
作者：
Nagao Y.;Yamaguchi M.;Watanabe S.;Ishioka N.S.;Kawachi N.;Watabe H.
~(211)At是很有前景的靶向阿尔法治疗的放射性同位素之一。优化治疗策略以及确定特定药物对特定患者的适宜性需要成像靶向放射治疗剂在肿瘤和正常组织中的随时间变化的分布。由于~(211)At的生物分布与碘的不同，直接对~(211)At进行成像是非常必要的。在之前的Astatine-211康普顿成像研究中，由于钚K壳层X射线引起的随机符合事件占主导地位，似乎会导致计数饱和。因此，重合时间窗口的优化对于减少随机重合事件很重要。在这项研究中，我们优化了康普顿相机的符合时间窗，并提高了Astatine-211成像的灵敏度、噪声和空间分辨率。
Astatine-211 is one of the promising radioisotopes for targeted alpha therapy. Optimising treatment strategies as well as determining the suitability of a given agent for a particular patient requires to image the time-dependent distribution of the targeted radiotherapeutic agent both in tumours and in normal tissues. Since the biodistribution of astatine is different from that of iodine, imaging astatine-211 directly is essential. In the previous study of astatine-211 Compton imaging, random coincidence events due to polonium K-shell X-rays were dominant and seemed to cause saturation of counts. Thus optimisation of the coincidence time windows is important to reduce random coincidence events. In this study, we have optimised the coincidence time windows of a Compton camera and improved the sensitivity, noise and spatial resolution of astatine-211 imaging.