Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?

Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
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热休克蛋白是否控制炎症性疾病中 T 细胞调节的平衡?

DOI:
10.1016/s0167-5699(98)01283-3
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发表时间:
1998
期刊:
Immunology today
影响因子:
--
通讯作者:
M. Wauben
M. Wauben
中科院分区:
--
文献类型:
--
作者:
W. Eden;R. Zee;Alberta G. A. Paul;B. Prakken;U. Wendling;Stephen M. Anderton;M. Wauben

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热休克蛋白(Hsps)是显着的免疫原性,尽管他们的高度进化保守。对自身免疫性疾病的实验和临床观察表明,对Hsps的免疫应答在疾病过程中自发产生。根据目前的证据,Willem货车Eden和同事认为,这种对Hsps的免疫是具有疾病控制潜力的正常免疫调节T细胞应答的一部分。
Heat shock proteins (Hsps) are remarkably immunogenic, despite their high degree of evolutionary conservation. Experimental and clinical observations on autoimmune diseases indicate that immune responses to Hsps arise spontaneously during the disease process. Based on current evidence, Willem van Eden and colleagues argue that such immunity to Hsps is part of a normal immunoregulatory T-cell response with disease controlling potential.
从异位大鼠同种异体心脏移植物中分离的淋巴细胞的热休克蛋白反应性。
DOI: --
发表时间: 1995
期刊: Transplantation.
影响因子: --
作者:
Moliterno,R;Valdivia,L;Pan,F;Duquesnoy,RJ
通讯作者: Duquesnoy,RJ