Familial relative risk of colorectal cancer: a population-based study
Familial relative risk of colorectal cancer: a population-based study
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DOI：
10.1016/s0959-8049(03)00420-9
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发表时间：
2003-09-01
影响因子：
8.4
通讯作者：
Gignoux, M
中科院分区：
文献类型：
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作者：
Andrieu, N;Launoy, G;Gignoux, M
本研究旨在评估结直肠癌(CRC)的家族性相对风险及其随年龄和性别的变化。1993年至1998年在法国进行了一项以人口为基础的家庭研究，其中包括761个家庭。家族性结直肠癌风险是通过对亲属的队列分析来估计的。除了先证者或亲属属于最年轻的年龄组外，没有发现随着年龄的增加，结直肠癌风险明显降低。亲属和先证者的年龄对结直肠癌风险的影响因性别而异。在60岁以下先证者的男性亲属中，结直肠癌的累积风险比女性亲属更早增加。这一结果表明，女性特有的机制可能与遗传因素相互作用，解释了有男性先证者和女性先证者的家庭累积风险的差异。(C)2003爱思唯尔有限公司。保留所有权利。
This study aimed to assess the familial relative risk for colorectal cancer (CRC) and its variation according to age and gender. A population-based family study was carried out in France, from 1993 to 1998, including 761 families. Familial CRC risks were estimated from a cohort analysis of the relatives. No obvious decrease in CRC risk was found with increasing age, except when either the proband, or the relative, were in the youngest age class. The effect of the relatives' and probands' ages on the CRC risk differed according to their gender. The cumulative risk of CRC increased at an earlier age in male relatives of probands younger than 60 years of age, than in female relatives. This result suggests that mechanisms specific to females, possibly interacting with genetic factors, explain the difference in the cumulative risks between families with male and female probands. (C) 2003 Elsevier Ltd. All rights reserved.