Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
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DOI：
10.1200/jco.2006.05.8172
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发表时间：
2007-03-01
影响因子：
45.3
通讯作者：
Allegra, Carmen J.
中科院分区：
文献类型：
--
作者：
Kim, George P.;Colangelo, Linda H.;Allegra, Carmen J.
PurposeThe作用的高度微卫星不稳定性（MSI-H）作为一个标志物，以预测从辅助化疗的好处仍然是unclear.Patients和MethodsTo帮助定义其影响，我们进行了一项分析，国家手术辅助乳腺和肠道项目（NSABP）的患者被随机分配到一个单独的手术组（未治疗队列）和患者分配到一个辅助氟尿嘧啶（FU）治疗组（治疗队列）。结果542例患者中有98例（18.1%）出现MSI-H，MSI-H与突变型p53状态呈强负相关（P < 0.05），MSI-H与突变型p53状态呈负相关（P < 0.05），MSI-H与突变型p53状态呈负相关（P < 0.05）。
PurposeThe role of high-degree microsatellite instability (MSI-H) as a marker to predict benefit from adjuvant chemotherapy remains unclear.Patients and MethodsTo help define its impact, we conducted an analysis of National Surgical Adjuvant Breast and Bowel Project (NSABP) patients who were randomly assigned to a surgery-alone group (untreated cohort) and patients assigned to an adjuvant fluorouracil (FU) -treated group (treated cohort). MSI-H and other potential markers were assessed (TGF-BRII, p53, thymidylate synthase, and Ki67).ResultsIn all, 98 (18.1 %) of 542 patients exhibited MSI-H, and there was a strong inverse relationship between MSI-H and mutant p53 status (P