Development of Activity-Based Proteomic Probes for Protein Citrullination.
Development of Activity-Based Proteomic Probes for Protein Citrullination.
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DOI：
10.1007/82_2018_132
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发表时间：
2019
影响因子：
--
通讯作者：
Thompson PR
中科院分区：
文献类型：
--
作者：
Nemmara VV;Thompson PR
蛋白质精氨酸脱亚胺酶（PAD）催化肽基精氨酸的翻译后脱亚胺化以形成肽基瓜氨酸。这种修饰在多种炎性疾病和某些癌症中增加。PAD调节多种信号传导途径，包括凋亡、终末分化和转录调节。开发了基于活性的蛋白质谱（ABPP）探针，以了解PAD在体内的作用，并研究瓜氨酸蛋白在各种病理条件下的作用。此外，这些ABPP已被用作高通量抑制剂发现的平台。本综述将展示针对PAD的ABPP的发展。此外，它还提供了PAD结构和功能的简要概述沿着PAD抑制剂开发的最新进展。
Protein arginine deiminases (PADs) catalyze the post-translational deimination of peptidyl arginine to form peptidyl citrulline. This modification is increased in multiple inflammatory diseases and in certain cancers. PADs regulate a variety of signaling pathways including apoptosis, terminal differentiation, and transcriptional regulation. Activity-based protein profiling (ABPP) probes have been developed to understand the role of the PADs in vivo and to investigate the effect of protein citrullination in various pathological conditions. Furthermore, these ABPPs have been utilized as a platform for high-throughput inhibitor discovery. This review will showcase the development of ABPPs targeting the PADs. In addition, it provides a brief overview of PAD structure and function along with recent advances in PAD inhibitor development.
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影响因子：
7.3
作者：
Causey, Corey P.;Jones, Justin E.;Slack, Jessica L.;Kamei, Daisuke;Jones, Larry E., Jr.;Subramanian, Venkataraman;Knuckley, Bryan;Ebrahimi, Pedram;Chumanevich, Alexander A.;Luo, Yuan;Hashimoto, Hiroshi;Sato, Mamoru;Hofseth, Lorne J.;Thompson, Paul R.
通讯作者：
Thompson, Paul R.
影响因子：
3.5
作者：
Dreyton CJ;Anderson ED;Subramanian V;Boger DL;Thompson PR
通讯作者：
Thompson PR
影响因子：
2.9
作者：
Bicker, Kevin L.;Thompson, Paul R.
通讯作者：
Thompson, Paul R.
影响因子：
13.6
作者：
Ghari F;Quirke AM;Munro S;Kawalkowska J;Picaud S;McGouran J;Subramanian V;Muth A;Williams R;Kessler B;Thompson PR;Fillipakopoulos P;Knapp S;Venables PJ;La Thangue NB
通讯作者：
La Thangue NB
影响因子：
62.1
作者：
Fuhrmann, Jakob;Clancy, Kathleen W.;Thompson, Paul R.
通讯作者：
Thompson, Paul R.