Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants.
Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants.
复制标题
使用小分子佐剂克服革兰氏阴性菌的内在耐药性。
DOI：
10.1016/j.bmcl.2022.129113
复制
发表时间：
2023
影响因子：
2.7
通讯作者：
Melander,Christian
中科院分区：
文献类型：
--
作者：
Melander,RobertaJ;Mattingly,AnneE;Nemeth,AnsleyM;Melander,Christian
Gram-negative bacteria are intrinsically resistant to many classes of antibiotics, predominantly due to the impermeability of the outer membrane and the presence of efflux pumps. Small molecule adjuvants that circumvent these resistance mechanisms have the potential to expand therapeutic options for treating Gram-negative infections to encompass antibiotic classes that are otherwise limited to treating Gram-positive infections. Adjuvants that effect increased antibiotic permeation, either by physical disruption of the outer membrane or through interference with synthesis, transport, or assembly of membrane components, and adjuvants that limit efflux, are discussed as potential avenues to overcoming intrinsic resistance in Gram-negative bacteria.
