A case of minimal change nephrotic syndrome with pregnancy
A case of minimal change nephrotic syndrome with pregnancy
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DOI：
10.1007/s13730-020-00568-5
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发表时间：
2021-01
期刊：
影响因子：
1
通讯作者：
M. Horigome;R. Kobayashi;Masaaki Hanaoka;S. Kinguchi;T. Kanaoka;Y. Toya;H. Wakui;K. Tamura
中科院分区：
文献类型：
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作者：
M. Horigome;R. Kobayashi;Masaaki Hanaoka;S. Kinguchi;T. Kanaoka;Y. Toya;H. Wakui;K. Tamura
一名32岁的日本妇女在怀孕8周时因全身性水肿、低白蛋白血症和严重蛋白尿入院。患者有全身性脱发和偏头痛病史。我们诊断为肾病综合征，肾活检显示微小病变肾病综合征（MCNS）。我们给予1000毫克/天的甲基强的松龙3天。口服皮质类固醇治疗后，每天40毫克的泼尼松龙。我们在考虑器官发生后仔细选择了合并用药。在肾活检前后，我们酌情给予肝素、抗凝血酶III和免疫球蛋白药物。患者在治疗第8天达到完全缓解，并在妊娠37周时生下一名男孩，无复发。妊娠期MCNS是罕见的，没有既定的治疗方法。总之，我们提出了一个怀孕的妇女与MCNS在器官形成的情况下。早期治疗可以为母亲和孩子提供良好的预后。
A 32-year-old Japanese woman at 8 weeks of gestation was admitted to our hospital for systemic edema, hypoalbuminemia, and severe proteinuria. The patient had a history of generalized alopecia and migraine. We diagnosed nephrotic syndrome, and renal biopsy revealed minimal change nephrotic syndrome (MCNS). We administered 1000 mg/day of methylprednisolone for 3 days. Oral corticosteroid therapy was followed by 40 mg of prednisolone daily. We carefully selected concomitant medication after considering organogenesis. Before and after renal biopsy, we administered heparin, antithrombin III, and immunoglobulin agents as appropriate. The patient achieved complete remission on day 8 of treatment and gave birth to a boy at 37 weeks of gestation without recurrence. MCNS during pregnancy is rare, and there is no established treatment. In conclusion, we present a case of a pregnant woman with MCNS during organogenesis. Early treatment initiation can provide a good prognosis for both mother and child.