LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma.
LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma.
复制标题
LncRNA MALAT1 作为竞争性内源性 RNA，通过在透明细胞肾癌中海绵 miR-200 来调节 ZEB2 表达。
DOI：
10.18632/oncotarget.5357
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发表时间：
2015-11-10
期刊：
影响因子：
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通讯作者：
Huang Q
中科院分区：
文献类型：
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作者：
Xiao H;Tang K;Liu P;Chen K;Hu J;Zeng J;Xiao W;Yu G;Yao W;Zhou H;Li H;Pan Y;Li A;Ye Z;Wang J;Xu H;Huang Q
长链非编码RNA（lncRNA）在癌症的发展中起着关键作用。LncRNA转移相关肺腺癌转录本1（MALAT 1）与肺癌、膀胱癌等多种肿瘤的发生有关，本研究从肿瘤基因组图谱（TCGA）数据库中发现，MALAT 1在肾透明细胞癌（KIRC）中存在较高的倍数变化（肿瘤/正常），并与miR-200 s家族呈负相关。我们进一步证明了MALAT 1通过海绵状miR-200在体外和体内促进KIRC增殖和转移。此外，miR-200 c可部分逆转MALAT 1对KIRC增殖和转移的刺激作用。总之，我们揭示了MALAT 1/miR-200 s/ZEB 2通路的一个分支，它调节KIRC的进展。抑制MALAT 1表达可能是KIRC治疗的一个有前途的策略。
Long non-coding RNA (lncRNAs) play a critical role in the development of cancers. LncRNA metastasis-associated lung adenocarcinoma transcript 1(MALAT1) has recently been identified to be involved in tumorigenesis of several cancers such as lung cancer, bladder cancer and so on. Here, we found that MALAT1 exist a higher fold change (Tumor/Normal) in clear cell kidney carcinoma (KIRC) from The Cancer Genome Atlas (TCGA) Data Portal and a negative correlation with miR-200s family. We further demonstrated MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo. In addition, miR-200c can partly reverse the MALAT1′s stimulation on proliferation and metastasis in KIRC. In summary we unveil a branch of the MALAT1/miR-200s/ZEB2 pathway that regulates the progression of KIRC. The inhibition of MALAT1 expression may be a promising strategy for KIRC therapy.