Repeatability and reproducibility of pachymetric mapping with visante anterior segment-optical coherence tomography
Repeatability and reproducibility of pachymetric mapping with visante anterior segment-optical coherence tomography
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DOI：
10.1167/iovs.07-0591
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发表时间：
2007-12-01
影响因子：
4.4
通讯作者：
Lam, Dennis S. C.
中科院分区：
文献类型：
--
作者：
Mohamed, Shaheeda;Lee, Gary K. Y.;Lam, Dennis S. C.
目的.目的：探讨前节光学相干断层扫描（AS-OCT）测量中央和周边角膜厚度的可重复性和可重复性。一项观察性横断面研究包括两组：27只健康眼和20只圆锥角膜眼。每例受试者均接受了AS-OCT扫描，以确定观察者内重复性、观察者间重现性，此外，对于健康眼，还确定了直径最大为10 mm的角膜不同区域的会话间重现性。主要结果测量是再现性和重复性系数、组内相关系数和由Visante AS-OCT（Carl Zeiss Meditec，Inc.，都柏林，CA）测厚标测方案。健康人的重复性系数小于2%，圆锥角膜患者的重复性系数小于3%。正常人和圆锥角膜患者的重复性系数分别小于2%和4%。不同观察者或不同访视期间获得的扫描结果之间无显著差异。健康人和圆锥角膜患者的组内相关系数分别大于0.99和0.97。使用Visante AS-OCT的角膜厚度测量标测方案，这些结果表明，健康受试者和圆锥角膜患者的中央和外周角膜厚度测量具有可重复性和可再现性。
PURPOSE. To determine the repeatability and reproducibility of central and peripheral corneal pachymetry mapping with anterior segment-optical coherence tomography (AS-OCT).METHODS. An observational cross-sectional study involving two groups: 27 healthy eyes and 20 eyes with keratoconus. Each subject underwent scanning sessions with AS-OCT to determine intraobserver repeatability, interobserver reproducibility, and additionally for healthy eyes, intersession reproducibility for different regions of the cornea up to a 10-mm diameter. Main outcome measures were reproducibility and repeatability coefficients, intraclass correlation coefficients, and coefficients of variation of the average central (0-2 mm), pericentral (2-5 mm), transitional (5-7 mm), and peripheral (7-10 mm) corneal thicknesses generated by the Visante AS-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) pachymetric mapping protocol.RESULTS. The coefficients of repeatability were less than 2% in healthy subjects and less than 3% in patients with keratoconus. The reproducibility coefficients were less than 2% and 4% in healthy subjects and patients with keratoconus, respectively. There was no significant difference between scans obtained by different observers or during different visits. The intraclass correlation coefficients were greater than 0.99 and 0.97 in healthy subjects and patients with keratoconus, respectively.CONCLUSIONS. With the pachymetric mapping protocol of Visante AS-OCT, these results suggest that central and peripheral corneal thickness measurements in healthy subjects and in eyes with keratoconus are repeatable and reproducible.