A novel bivalent morphine/heroin vaccine that prevents relapse to heroin addiction in rodents
A novel bivalent morphine/heroin vaccine that prevents relapse to heroin addiction in rodents
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DOI：
10.1016/j.vaccine.2006.01.047
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发表时间：
2006-04-12
期刊：
影响因子：
5.5
通讯作者：
Leff, P
中科院分区：
文献类型：
--
作者：
Anton, B;Leff, P
临床前和临床研究都使疫苗作为治疗药物成瘾的新型治疗药物成为可能。到目前为止，还没有报告显示开发出用于治疗人类对此类化合物成瘾的阿片类候选疫苗的结构模型。在这里，我们报告了一种新的针对吗啡/海洛因的双价疫苗的结构配方的初步开发。这种疫苗能够触发和建立对半致敏药物的高滴度抗体反应，抗体显示出与吗啡和海洛因相同的特异性。这种抗体不能交叉识别结构不同的阿片类药物。此外，这种疫苗的潜在治疗效果的评估旨在通过在大鼠自我给药模型中使用海洛因给药时间表来预防复发。针对海洛因的抗体阻断了它在啮齿动物身上的增强作用。该疫苗中使用的载体蛋白类型允许进一步评估其在防止人类海洛因成瘾复发方面的潜在治疗价值。(C)2006爱思唯尔有限公司。保留所有权利。
Both pre-clinical and clinical studies make feasible the use of vaccines as novel therapeutic medications to treat drug addiction. No reports to date have shown the development of structural models of opiate candidate vaccines for treating human addiction to such compounds. Here we report on the initial development of a novel structural formulation of a bi-valent vaccine against morphine/heroin. This vaccine was able to trigger and establish a high titer antibody response to haptenized drug with antibodies displaying equivalent specificities for both morphine and heroin. Such antibodies did not cross-recognize structurally dissimilar opiate medications. Furthermore, the evaluation of the potential therapeutic effectiveness of this vaccine was targeted to relapse prevention using a schedule of heroin delivery in the rat self-administration model. Antibodies against heroin blocked its reinforcing effects in rodents. The type of carrier protein used in this vaccine allows further evaluation of its potential therapeutic value for preventing relapse to heroin addiction in humans. (c) 2006 Elsevier Ltd. All rights reserved.