Growth hormone (GH) secretion from human lymphocytes is up-regulated by GH, but not affected by insulin-like growth factor-I.
Growth hormone (GH) secretion from human lymphocytes is up-regulated by GH, but not affected by insulin-like growth factor-I.
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人类淋巴细胞的生长激素 (GH) 分泌量受到 GH 的上调，但不受胰岛素样生长因子-I 的影响。
DOI：
10.1210/jcem.76.4.8473409
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
H. Kurahachi
中科院分区：
文献类型：
--
作者：
N. Hattori;K. Shimomura;T. Ishihara;K. Moridera;M. Hino;K. Ikekubo;H. Kurahachi
本文研究了6名正常人植物血凝素（PHA）刺激淋巴细胞分泌生长激素（GH）的规律。将外周血单核细胞与PHA（10 μ g/mL）在存在不同量的重组人GH（0-100 ng/L）和/或重组人胰岛素样生长因子-I（0-1000 μ g/L）的情况下孵育，并且通过高灵敏度酶免疫测定法测量分泌的GH。PHA刺激的淋巴细胞在所有受试者中分泌免疫反应性GH（13.6 +/- 2.4 ng/L）。外源性GH以剂量依赖方式上调GH分泌，而IGF-I既不影响基础GH分泌，也不影响外源性GH的上调。这些发现表明内分泌系统和免疫系统之间GH分泌调节的差异。
Regulation of GH secretion from phytohemagglutinin (PHA)-stimulated lymphocytes was investigated in six normal subjects. Peripheral blood mononuclear cells were incubated with PHA (10 micrograms/mL) in the presence of various amounts of recombinant human GH (0-100 ng/L) and/or recombinant human insulin-like growth factor-I (0-1000 micrograms/L), and the secreted GH was measured by a highly sensitive enzyme immunoassay. PHA-stimulated lymphocytes secreted immunoreactive GH in all subjects (13.6 +/- 2.4 ng/L). Exogenous GH up-regulated the GH secretion in a dose-dependent manner, while IGF-I did not affect either basal GH secretion or the up-regulation by exogenous GH. These findings suggest a difference in the regulation of GH secretion between endocrine and immune systems.
人类 B 淋巴细胞分泌胰岛素样生长因子：正常和侏儒受试者细胞的比较。
DOI：
10.1210/jcem-69-5-978
发表时间：
1989
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Merimee,TJ;Grant,MB;Broder,CM;Cavalli-Sforza,LL
通讯作者：
Cavalli-Sforza,LL