Capsulate bacteria and the lung
Capsulate bacteria and the lung
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DOI：
10.1093/bmb/61.1.63
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发表时间：
2002-01-01
影响因子：
6.7
通讯作者：
Moxon, ER
中科院分区：
文献类型：
--
作者：
Buttery, J;Moxon, ER
荚膜细菌引起了世界范围内所有年龄段的大多数社区获得性肺炎。它们通过不同荚膜多糖的毒力因子结合在一起，使它们能够逃避吞噬作用。所有这些都会引起呼吸道以外的侵袭性疾病，包括败血症和中枢神经系统感染。疫苗开发的最新进展使荚膜多糖成为所有年龄段疫苗策略的可实现目标，在能够负担这些新疫苗的国家，已经看到了对肺炎链球菌和流感嗜血杆菌B型肺炎的影响。
Capsulate bacteria cause the majority of community-acquired pneumonia presenting to hospital world-wide, at all ages. They are united by the virulence factor of their differing capsular polysaccharides, enabling them to evade phagocytosis. All cause invasive disease beyond the respiratory tract, including septicaemia and central nervous system infection. Recent advances in vaccine development have made the capsular polysaccharide an achievable target for vaccine strategies across all ages, with impacts already seen upon Streptococcus pneumoniae and Haemophilus influenzae type b pneumonia in countries able to afford these new vaccines.