Role of hepatocyte growth factor and its receptorc-met in multiple myeloma
Role of hepatocyte growth factor and its receptorc-met in multiple myeloma
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DOI：
10.1007/bf02821933
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发表时间：
1998-09
期刊：
影响因子：
3.4
通讯作者：
C. Seidel;M. Børset;H. Hjorth-Hansen;A. Sundan;A. Waage
中科院分区：
文献类型：
--
作者：
C. Seidel;M. Børset;H. Hjorth-Hansen;A. Sundan;A. Waage
多发性骨髓瘤的特征是恶性浆细胞的克隆性扩增。最近，我们报道了一种新的细胞因子肝细胞生长因子（HGF）及其受体与该病的关系。在这里，我们审查的意见，相关HGF与骨髓瘤。恶性浆细胞产生HGF并表达受体c-met。许多患者具有升高的HGF水平，这在存活率和对治疗的反应方面都是不利的。肝细胞生长因子在这种疾病中可能的生物学作用进行了讨论，特别侧重于骨稳态和硫酸乙酰肝素蛋白多糖的结合。
Multiple myeloma is characterised by the clonal expansion of malignant plasma cells. Recently, we reported that a new cytokine, hepatocyte growth factor (HGF), and its receptorc-metare related to this disease. Here we review the observations that associate HGF with myeloma. Malignant plasma cells produce HGF and express the receptorc-met. Many patients have elevated HGF levels, which is unfavourable both in terms of survival and response to treatment. Possible biological roles of HGF in this disease are discussed, with special focus on bone homeostasis and its binding to heparan sulphate proteoglycans.