Anxiety and depression following cumulative low-level exposure to organophosphate pesticides
Anxiety and depression following cumulative low-level exposure to organophosphate pesticides
复制标题
DOI：
10.1016/j.envres.2016.08.020
复制
发表时间：
2016-11-01
影响因子：
8.3
通讯作者：
Ross, Sarah Mackenzie
中科院分区：
文献类型：
--
作者：
Harrison, Virginia;Ross, Sarah Mackenzie
先前的研究表明，有农药中毒史的个体患精神疾病的风险增加（Freire 和 Koifman，2013），但有关累积低水平暴露影响的研究结果并不一致。本研究的目的是调查有低水平接触有机磷农药历史的养羊户 (1) 在主观症状问卷中报告的心理困扰程度是否比未接触有机磷农药的对照者 (2) 更高，也比未接触有机磷农药的对照者更符合国际公认的精神疾病诊断标准。对 127 名养羊户进行了评估，并与 78 名未暴露的对照组进行了比较，在性别、教育程度、智力水平、工作状况和居住地区方面进行了匹配。自我报告措施和结构化临床访谈都用于评估心理健康状况。当使用自我报告问卷来评估情绪时，即使考虑到压力生活事件、人口统计和身体健康因素，暴露人群的焦虑和抑郁发生率也显着升高。然而，当使用诊断访谈来评估情绪时，这种模式只适用于焦虑。 (C) 2016 Elsevier Inc. 保留所有权利。
Previous research suggests that individuals with a prior history of pesticide poisoning are at increased risk of psychiatric disorder (Freire and Koifman, 2013), but findings regarding the impact of cumulative low-level exposure are inconsistent. The aim of the current study was to investigate whether sheep farmers with a history of low-level exposure to organophosphate pesticides (1) report a higher level of psychological distress on subjective symptom questionnaires, compared to unexposed controls (2) also meet internationally agreed diagnostic criteria for a psychiatric disorder more often than unexposed controls. 127sheep farmers were evaluated and compared to 78 unexposed controls, matched in terms of gender, education, level of intelligence, working status and area of residence. Both self-report measures and structured clinical interviews were used to assess mental health. The exposed cohort reported significantly higher rates of anxiety and depression when self-report questionnaires were used to evaluate mood, even when stressful life events, demographic and physical health factors were taken into account. However, when diagnostic interviews were used to assess mood, this pattern only held true for anxiety. (C) 2016 Elsevier Inc. All rights reserved.