Succinate dehydrogenase activities of fibers in the rat extensor digitorum longus, soleus, and cardiac muscles
Succinate dehydrogenase activities of fibers in the rat extensor digitorum longus, soleus, and cardiac muscles
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DOI：
10.1679/aohc.62.393
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发表时间：
1999-10-01
影响因子：
--
通讯作者：
Ishihara, A
中科院分区：
文献类型：
--
作者：
Nakatani, T;Nakashima, T;Ishihara, A
采用组织化学定量方法和计算机图像处理系统，对10周龄雄性大鼠趾长伸肌和比目鱼肌（SOL）和左心室肌（HEART）浅区（EDLs）和深区（EDLd）不同类型纤维的琥珀酸脱氢酶（SDH）活性和截面积（CSA）进行了测定。根据其组织化学评估的腺苷三磷酸酶活性，将纤维分为I型、IIA型、IIR型或IIC型。IIA型纤维的平均SDH活性高于IIB型纤维，而CSA小于IIB型纤维，SOL中IIA型纤维的平均SDH活性高于I型纤维。心脏中的纤维表现出最高的平均SDH活性和最小的平均CSA在所有纤维类型的肌肉检查。不同肌纤维类型的CSA与SDH活性呈负相关。这些数据表明，肌肉中纤维的SDH活性是纤维类型和大小特异性的，并且心脏左心室肌中纤维的最高SDH活性有助于其功能特性，即，高抗疲劳性。
Succinate dehydrogenase (SDH) activities and cross-sectional areas (CSAs) of different types of fibers in the superficial (EDLs) and deep (EDLd) regions of the extensor digitorum longus and soleus (SOL) muscles and the left ventricular muscle of the heart (HEART) of 10-week-old male rats were determined using quantitative histochemistry and a computer-assisted image processing system. The fibers were classified as type I, type IIA, type IIR, or type IIC according to their histochemically assessed adenosine triphosphatase activities. The mean SDH activity was higher and the mean CSA was smaller in type IIA fibers than in type IIB fibers in both the EDLs and EDLd, The mean SDH activity of type IIA fibers in the SOL was higher than that of type I fibers. Fibers in the HEART showed the highest mean SDH activity and the smallest mean CSA among all fiber types in the muscles examined. There was an inverse correlation between CSA and SDH activity for the different fiber types in different muscles. These data suggest that the SDH activity of fibers in muscle is fiber type- and size-specific, and that the highest SDH activity of fibers in the left ventricular muscle of the heart contributes to their functional properties, i.e., high fatigue resistance.