Toward a Noninvasive Automatic Seizure Control System in Rats With Transcranial Focal Stimulations via Tripolar Concentric Ring Electrodes
Toward a Noninvasive Automatic Seizure Control System in Rats With Transcranial Focal Stimulations via Tripolar Concentric Ring Electrodes
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DOI：
10.1109/tnsre.2012.2197865
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发表时间：
2012-07-01
影响因子：
4.9
通讯作者：
Besio, Walter G.
中科院分区：
文献类型：
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作者：
Makeyev, Oleksandr;Liu, Xiang;Besio, Walter G.
癫痫症影响着大约 1% 的世界人口。抗癫痫药物对大约30%的患者无效并且有副作用。我们正在开发一种无创或微创经颅局灶电刺激系统，通过新型三极同心环电极来控制癫痫发作。在这项研究中，我们证明了自动癫痫控制系统在通过单次和多次刺激由戊四唑诱导癫痫发作的大鼠中的可行性。这些刺激由实时电图癫痫活动检测器自动触发，该检测器基于累积和算法和广义似然比测试的检测的分离组合。测试集 (n = 13) 的平均癫痫发作检测准确率为 76.14%。 76.92% 的病例中，电图癫痫发作活动的检测是在早期行为癫痫发作活动之前完成的。在 70% 的病例中，与对照组相比，自动触发的刺激显着降低了一次刺激组的电图癫痫发作活动强度（p = 0.001）。据我们所知，这是第一个基于无创电脑刺激的闭环自动癫痫控制系统，使用三极同心环电极电图癫痫活动作为反馈。
Epilepsy affects approximately 1% of the world population. Antiepileptic drugs are ineffective in approximately 30% of patients and have side effects. We are developing a noninvasive, or minimally invasive, transcranial focal electrical stimulation system through our novel tripolar concentric ring electrodes to control seizures. In this study, we demonstrate feasibility of an automatic seizure control system in rats with pentylenetetrazole-induced seizures through single and multiple stimulations. These stimulations are automatically triggered by a real-time electrographic seizure activity detector based on a disjunctive combination of detections from a cumulative sum algorithm and a generalized likelihood ratio test. An average seizure onset detection accuracy of 76.14% was obtained for the test set (n = 13). Detection of electrographic seizure activity was accomplished in advance of the early behavioral seizure activity in 76.92% of the cases. Automatically triggered stimulation significantly (p = 0.001) reduced the electrographic seizure activity power in the once stimulated group compared to controls in 70% of the cases. To the best of our knowledge this is the first closed-loop automatic seizure control system based on noninvasive electrical brain stimulation using tripolar concentric ring electrode electrographic seizure activity as feedback.