Multiple myeloma in Olmsted County, Minnesota, 1945-1964.
Multiple myeloma in Olmsted County, Minnesota, 1945-1964.
复制标题
1945 年至 1964 年，明尼苏达州奥姆斯特德县的多发性骨髓瘤。
作者：
R. Kyle;F. Nobrega;L. Kurland
对1945年至1964年明尼苏达州奥姆斯特德县的所有确诊为多发性骨髓瘤的居民进行了鉴定和回顾。35例中有33例有病理学资料可供再次确诊。在其余两个案件的诊断是基于X线检查结果和蛋白质异常，以及一个典型的临床图片。男性的发病率是女性的1.9倍。在本研究所涵盖的20年期间，总人口的年平均发病率保持在3/100 000左右，如果计算30岁及30岁以上人口的年平均发病率，则为6.3/100 000。按居住地分列的发病率数字没有显示出城乡发病率的显著差异。在74%的死亡证明中，骨髓瘤被列为死亡原因。所有病例从发病开始的平均生存时间约为2年，中位生存期约为1年。按年龄划分的比率随着年龄的增长而增加，80岁及以上的男性居民的比率最高。
All cases of multiple myeloma diagnosed in bona fide residents of Olmsted County, Minnesota, during the years 1945 through 1964 were identified and reviewed. Pathologic material was available for reconfirmation of the diagnosis in 33 of the 35 cases reported. In the remaining two cases the diagnosis was based on roentgenologic findings and protein abnormalities as well as a typical clinical picture. The incidence rate for males was 1.9 times that for females. During the 20 year period covered in this study the average annual incidence rate in the total population has remained about 3/100,000 and when computed for persons 30 years of age and over, it is 6.3/100,000. Incidence figures by place of residence did not reveal a significant difference in the urban-rural rates. Myeloma was listed as a cause of death in 74 per cent of the death certificates. The mean survival time from onset in all cases was about 2 years, with a median survival of approximately 1 year. The age-specific rate increased with age, the highest rates being among male residents 80 years of age and older.