Accumulation of collagen in the uterus of the immature rat administered estradiol-17 beta.
Accumulation of collagen in the uterus of the immature rat administered estradiol-17 beta.
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给予雌二醇 17 β 的未成熟大鼠子宫中胶原蛋白的积累。
DOI：
10.1016/0006-2952(73)90252-9
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发表时间：
1973
影响因子：
5.8
通讯作者：
I. Tsai
中科院分区：
文献类型：
--
作者：
R. Salvador;I. Tsai
用5 μg雌二醇-17β连续4、5 d，测定未成熟大鼠和成年去卵巢大鼠子宫总蛋白和胶原蛋白含量。在未成熟的大鼠中，这种治疗导致子宫胶原含量增加3倍。在前三次雌二醇-17β剂量后，这种增加呈线性，并在大约5天后达到最大值。子宫总蛋白在整个试验期间均匀增加；因此，胶原蛋白占总蛋白质的百分比基本保持不变。这些结果表明，给予雌二醇-17β的未成熟大鼠子宫胶原含量的增加是由于蛋白质合成的一般刺激。雌酮、己烯雌酚或17-乙炔雌醇-3-甲基醚给予未成熟大鼠也会导致胶原蛋白和非胶原蛋白在子宫内积累。卵巢切除后21天，成年大鼠子宫的非胶原蛋白明显减少，通过连续4天给予雌二醇-17β，只能部分恢复。子宫胶原蛋白含量也明显降低，但雌二醇- 17β不增加。
The total protein and collagen content of the uterus was determined in both the immature and adult ovariectomized rat administered 5 μg estradiol-17β for 4 or 5 consecutive days. In the immature rat, this treatment results in a 3-fold increase in the collagen content of the uterus. This increase is linear following the first three doses of estradiol-17β and appears to reach a maximum after approximately 5 days. The total protein of the uterus also increases uniformly throughout the experimental period; therefore, the per cent collagen in total protein remains essentially unchanged. These results suggest that the increase in the collagen content of the uterus of the immature rat administered estradiol-17β is due to a general stimulation of protein synthesis. The administration of either estrone, diethylstilbestrol or 17-ethynylestradiol-3-methyl ether to the immature rat also causes collagenous and non-collagenous protein to accumulate in the uterus. There is a significant loss of noncollagenous protein from the uterus of the adult rat 21 days after ovariectomy, which is only partially restored by the administration of estradiol-17β for 4 consecutive days. The collagen content of the uterus is also reduced markedly and does not increase upon administration of estradio l17β.