Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer.
Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer.
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十二指肠溃疡对五肽胃泌素刺激酸分泌的敏感性增加。
DOI：
10.1172/jci107936
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
J. Walsh
中科院分区：
文献类型：
--
作者：
J. Isenberg;M. Grossman;V. Maxwell;J. Walsh
在 20 名十二指肠溃疡 (DU) 和 20 名非 DU 受试者中测量了分级剂量的五肽胃泌素（2.7-6,000 ng/kg·h）对胃酸分泌的影响。证实了许多先前的研究，DU 受试者中观察到的平均最高反应和平均计算的最大反应显着大于非 DU 受试者。根据根据基础分泌校正和最大分泌归一化的反应计算得出的半数最大反应的平均剂量（加或减 SE）为 ng/kg 次 h，在 DU 受试者中为 92.1 加或减 1.7，在非 DU 受试者中为 246.8 加或减 24.6，这是一个显着差异。通过平行线生物测定，非 DU 受试者所需的五肽胃泌素（95% 置信限 2.1-3.7）是 DU 最高反应的 2.8 倍。因此，本研究表明，与非DU受试者相比，DU患者不仅对五肽胃泌素的刺激分泌更多的酸，而且对五肽胃泌素的刺激更敏感，即需要更小的剂量来达到相同比例的最大反应。
The effect of graded doses of pentagastrin (2.7-6,000 ng/kg times h) on gastric acid secretion was measured in 20 duodenal ulcer (DU) and 20 non-DU subjects. Confirming many previous studies, the mean observed highest response and the mean calculated maximal response were significantly greater in DU than in non-DU subjects. The mean dose (plus or minus SE) in ng/kg times h for half maximal response, calculated from responses corrected for basal secretion and normalized for maximal secretion, was 92.1 plus or minus 1.7 in DU and 246.8 plus or minus 24.6 in non-DU subjects, a significant difference. By parallel line bioassay non-DU subjects required 2.8 times more pentagastrin (95% confidence limits 2.1-3.7) than DU highest response. Thus, this study shows that, compared with non-DU subjects, DU patients not only secrete more acid in response to stimulation by pentagastrin but also are more sensitive to stimulation by pentagastrin, that is, need smaller doses to achieve the same fraction of maximal response.