Identification of viruses in patients with postviral olfactory dysfunction
Identification of viruses in patients with postviral olfactory dysfunction
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DOI：
10.1097/01.mlg.0000249922.37381.1e
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发表时间：
2007-02-01
期刊：
影响因子：
2.6
通讯作者：
Murakami, Shingo
中科院分区：
文献类型：
--
作者：
Suzuki, Motohiko;Saito, Koichi;Murakami, Shingo
目的：病毒感染后嗅觉功能障碍（PVOD）的致病病毒尚未确定。本研究的目的是调查PVOD患者的致病病毒。研究设计和方法。收集24例PVOD患者的鼻分泌物。我们调查了鼻分泌物中10种病毒的存在情况，并使用问卷调查、声反射测量和嗅觉测试检查了PVOD患者嗅觉功能障碍和鼻塞变化的时间过程。结果：10例鼻病毒感染者鼻病毒核酸电泳均阳性。鼻病毒也证实在4例患者的核苷酸序列。病毒血清型鉴定为人鼻病毒（HRV）-40、HRV-75、HRV-78和HRV-80。4例患者中有1例主诉嗅觉丧失，另1例主诉嗅觉障碍。嗅觉测试没有显示出显着改善后4，8，11，和24周的第一次访问的四名患者，虽然结果的声反射显着改善。4例患者中有2例在首次就诊后6个月仍主诉嗅觉功能障碍。冠状病毒和副流感病毒分别在1例患者中检出，EB病毒在3例患者中检出。结论.本研究首次在PVOD患者的鼻分泌物中检测到鼻病毒、冠状病毒、副流感病毒和EB病毒。此外，目前的研究表明，鼻病毒可以通过鼻阻塞以外的机制引起嗅觉功能障碍，鼻病毒可以诱导不同的严重程度和不同的时间过程的嗅觉功能障碍。
Objective: Causative viruses of postviral olfactory dysfunction (PVOD) have not yet been identified. The aim of this study was to investigate causative viruses in patients with PVOD. Study Design and Methods. Nasal discharge was collected from 24 patients with PVOD. We investigated the presence of 10 viruses in nasal discharge and examined the time course, with regard to changes in olfactory dysfunction and nasal obstruction in patients with PVOD, using questionnaires, acoustic rhinometry, and olfactory tests. Results: Rhinoviruses were detected in 10 patients by electrophoresis. Rhinoviruses were also confirmed in four patients by nucleotide sequences. Viral serotypes were identified to be human rhinovirus (HRV)-40, HRV-75, HRV-78, and HRV-80. One of the four patients complained of anosmia, whereas another complained of dysosmia. Olfactory testing did not show significant improvement at 4, 8, 11, and 24 weeks after the first visit in the four patients, although results of acoustic rhinometry significantly improved. Two of the four patients complained of olfactory dysfunction even 6 months after the first visit. Coronavirus and parainfluenza virus were detected in one patient each, and Epstein-Barr viruses were detected in three patients. Conclusions. This study for the first time detected rhinovirus, coronavirus, parainfluenza virus, and Epstein-Barr virus in nasal discharge of patients with PVOD. Furthermore, the present study suggests that rhinoviruses can cause olfactory dysfunction through mechanisms other than nasal obstruction and that rhinoviruses can induce various severities and different time courses of olfactory dysfunction.