MATHEMATICAL-MODEL TO ASSESS CHANGES IN BARORECEPTOR REFLEX
MATHEMATICAL-MODEL TO ASSESS CHANGES IN BARORECEPTOR REFLEX
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DOI：
10.1159/000169528
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发表时间：
1972-01-01
期刊：
影响因子：
1.9
通讯作者：
MANNING, JW
中科院分区：
文献类型：
--
作者：
KENT, BB;DRANE, JW;MANNING, JW
颈动脉窦压（CSP）与体循环动脉压（SAP）之间的数学模型解释了CSP和SAP之间的关系，准确率为96%。模型的4个参数都具有生理意义。它们包括：SAP控制的总范围（标识为A（1），单位为mm Hg）;反射反应的灵敏度（标识为A（2），单位为mm Hg-1）;可以引起相等的升压和降压反应的颈动脉窦压力（标识为A（3），单位为mm Hg），以及最大颈动脉窦刺激可以驱动SAP的下限（标识为A（4），单位为mm Hg）。可以从模型计算几个其他生理上有意义的参数，例如阈值、饱和度和颈动脉窦压力的设定点。实验干预的影响参数的变化，这些变化可以用来分析反射反应的变化。例如，从迷走神经切断术后反射反应的升高的增益A（2），可以推断主动脉压力感受器对颈动脉窦反射反应具有阻尼作用。
A mathematical model relating carotid sinus pressure (CSP) to systemic arterial pressure (SAP) explains the relationship between CSP and SAP with an accuracy of 96 %. The 4 parameters of the model are all physiologically meaningful. They include: the total range of control of SAP (identified as A(l), in mm Hg); the sensitivity of the reflex response (identified as A(2), in mm Hg-1); the carotid sinus pressure from which equal pressor and depressor responses may be elicited (identified as A(3), in mm Hg), and the lower limit to which SAP may be driven by maximal carotid sinus stimulation (identified as A(4), in mm Hg). Several other physiologically meaningful parameters can be calculated from the model, e.g. threshold, saturation, and set point for carotid sinus pressures. Experimental interventions are shown to effect changes in parameters, and these changes can be used to analyze alterations in the reflex response. For example, from the elevated gain, A(2), of the reflex response after vagotomy it can be deduced that the aortic baroreceptors have a damping effect on the carotid sinus reflex response.