First report on the detection of pectenotoxin groups in Chinese shellfish by LC-MS/MS
First report on the detection of pectenotoxin groups in Chinese shellfish by LC-MS/MS
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首次用LC-MS/MS检测中国贝类中果胶毒素群的报告
DOI：
10.1016/j.toxicon.2011.04.002
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发表时间：
2011-06-01
期刊：
影响因子：
2.8
通讯作者：
Liu, Lei
中科院分区：
文献类型：
--
作者：
Liu, Renyan;Liang, Yubo;Liu, Lei
中国的贝类样本是从中国沿海的不同地点采集的。用液-质联用法分析了这些贝类的下列毒素：冈田酸(OA)、藻毒素(DTXs)、海藻毒素(PTXs)、氮杂阿司匹酸(Azas)、藻毒素(YTXs)、螺内酯(SPXs)和裸子藻二胺(GYM)。结果表明，不同贝类采样点的亲脂毒素谱不同。除了OA、GORM和YTX衍生物外，PTX-2及其衍生物在以下中国贝类中也是首次发现：长牡蛎、猕猴和紫贻贝。在中国贝类中存在GYM、YTXs、OA和PTXs，这些贝类来自以前没有报道过DSP中性有毒化合物的地区。因此，应认真努力开展藻毒素监测计划，以检测海洋来源的生物材料中是否存在亲脂毒素，以确保中国海产品不会对健康构成风险。关于怀疑的致癌性，需要进一步研究有毒化合物的分布和浓度，以便进行长期风险评估，特别是与较低剂量的有毒化合物相关的亚急性和慢性毒性测试。(C)2011爱思唯尔有限公司。保留所有权利。
Chinese shellfish samples were harvested from different locations along the Chinese coast. These shellfish were analyzed by liquid chromatography in combination with mass spectrometry to detect the following toxins: okadaic acid (OA), dinophysistoxins (DTXs), petenotoxins (PTXs), azaspiracids (AZAs), yessotoxins (YTXs), spirlides (SPXs) and gymnodimines (GYM). The results revealed the lipophilic toxin profiles varied with shellfish sampling locations. In addition to OA, GYM and YTX derivatives, PTX-2 and its derivatives were found for the first time in the following Chinese shellfish: Crassostrea gigas, Mactra chinensis and Mytilus galloprovincialis. The presence of GYM, YTXs, OA and PTXs in Chinese shellfish collected from regions where no previous record of DSP-neutral toxic compounds was reported. Serious efforts should therefore be made to conduct a phycotoxin monitoring program to detect the presence of lipophilic toxins in biological materials of marine origin, which may ensure that Chinese seafood products do not present a health risk. With respect to suspected carcinogenicity, further research on the distribution and concentrations of toxic compounds are needed, in order to carry out long-term risk assessments, particularly sub-acute and chronic toxicity tests associated with of lower doses. (C) 2011 Elsevier Ltd. All rights reserved.