Animal Models of Osteoarthritis
Animal Models of Osteoarthritis
复制标题
DOI：
10.2174/157339708785133523
复制
发表时间：
2008-01-01
影响因子：
1.5
通讯作者：
Smith, Margaret M.
中科院分区：
文献类型：
--
作者：
Little, Christopher B.;Smith, Margaret M.
人类关节疾病，特别是骨关节炎（OA）的复杂病理生物学变化通常需要几十年的发展，并可能受到许多遗传和环境因素的影响。需要澄清的分子事件发生在关节组织中的发病和进展过程中的OA有必要使用的模型，虽然不完美，可以表现出许多的病理特征，表征人类疾病。体外研究已证明在定义关节组织（如软骨）降解中的特定分子和细胞事件方面非常宝贵。然而，为了充分理解不同疾病机制、关节组织和身体系统之间复杂的相互关系，在动物模型中研究OA是必要的。炎性关节病的模型已被证明可预测临床疗效，在动物中有益的疗法在治疗人类类风湿性关节炎中具有显著益处。虽然没有一种可用的OA动物模型可以真正被认为是预测性的，因为还没有抗OA疗法在人体试验中被证明是疾病修饰，但这种方法代表了发现新的抗OA治疗靶点和药物的基石。本文综述了OA的种类和模型，并讨论了它们的潜在用途。
The complex pathobiologic changes of human joint disease, particularly osteoarthritis (OA), normally take several decades to develop and may be influenced by a multitude of genetic and environmental factors. The need to clarify the molecular events that occur in joint tissues at the onset and during the progression of OA has necessitated the use of models, which, although imperfect, can exhibit many of the pathologic features that characterize the human disease. In vitro studies have proven invaluable in defining specific molecular and cellular events in degradation of joint tissues such as cartilage. However, to fully understand the complex inter-relationship between the different disease mechanisms, joint tissues and body systems, studying OA in animal models is necessary. Models of inflammatory arthropathies have proven predictive of clinical efficacy, with therapies that are beneficial in animals having significant benefit in treatment of rheumatoid arthritis in humans. While none of the available animal models of OA can truly be said to be predictive, as no anti-OA therapies have yet proven to be disease modifying in human trials, this approach represents a cornerstone for discovery of new anti-OA therapeutic targets and drugs. In this paper the available species and models of OA are reviewed and their potential utility discussed.