THE EFFECT OF CLOSTRIDIUM-WELCHII TYPE-D CULTURE FILTRATES ON THE PERMEABILITY OF THE MOUSE INTESTINE
THE EFFECT OF CLOSTRIDIUM-WELCHII TYPE-D CULTURE FILTRATES ON THE PERMEABILITY OF THE MOUSE INTESTINE
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DOI：
10.1002/path.1700710206
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发表时间：
1956-01-01
期刊：
影响因子：
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通讯作者：
BATTY, I
中科院分区：
文献类型：
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作者：
BULLEN, JJ;BATTY, I
当正常的成年小鼠接受5个大剂量的葡萄球菌α-抗毒素时，小而恒定的量被吸收到血液中，表明该肠道对该蛋白质非常有渗透性。吸收速率被用作肠道通透性的指数。尽管小鼠通常对单剂量浓缩梭状芽胞杆菌型D型滤液具有抗性，但每小时施用5剂，因此增加了肠的渗透性，从而吸收了致命的剂量。肠道渗透性的最大，最直接的提高是由整个培养物滤液产生的。渗透率的早期增加似乎是由于埃氏蛋白毒素造成的。渗透率的延迟增加是由于滤液中的其他一些因素或因素引起的。
When normal adult mice received 5 large oral doses of staphyl-ococcus alpha-antitoxin, small but constant amounts were absorbed into the blood, showing that the intestine is very slightly permeable to this protein. The rate of absorption was employed as an index of intestinal permeability. Although the mouse is normally resistant to a single dose of concentrated Clostridium welchii type-D filtrate, the administration of 5 doses at hourly intervals so increased the permeability of the intestine that a lethal dose was absorbed. The greatest and most immediate increase in the permeability of the intestine was produced by the whole culture filtrate. The early increase in permeability appears to be due to epsilon toxin; the delayed increase in permeability is due to some other factor or factors in the filtrate.